- Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells
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Lee SK, Park SM, Im C
- KMID: 2285430
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):423-429.
- doi: 10.4196/kjpp.2011.15.6.423
B13 analogues are being considered as therapeutic agents for cancer cells, since B13 is a ceramide analogue and inhibits ceramidase to promote apoptosis in cancer cells. B13 sulfonamides are assumed... -
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- A molecular model of a point mutation (Val297Met) in the serine protease domain of protein C
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Song KS, Park YS, Choi JR, Kim HK, Park Q
- KMID: 755027
- Exp Mol Med.
- 1999 Mar;31(1):47-51.
A heterozygous GTG to ATG (Val297Met) mutation was detected in a patient with inherited protein C deficiency and deep vein thrombosis. Cosegregation of the mutation with protein C deficiency was observed through... -
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- Poor Prognostic Implication of ASXL1 Mutations in Korean Patients With Chronic Myelomonocytic Leukemia
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Kim HY, Lee KO, Park S, Jang JH, Jung CW, Kim SH, Kim HJ
- KMID: 2429113
- Ann Lab Med.
- 2018 Nov;38(6):495-502.
- doi: 10.3343/alm.2018.38.6.495
BACKGROUND: Molecular genetic abnormalities are observed in over 90% of chronic myelomonocytic leukemia (CMML) cases. Recently, several studies have demonstrated the negative prognostic impact of ASXL1 mutations in CMML patients.... -
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- Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells
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Kim YJ, Kim EA, Sohn UD, Yim CB, Im C
- KMID: 2071718
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):441-447.
- doi: 10.4196/kjpp.2010.14.6.441
B13, a ceramide analogue, is a ceramidase inhibitor and induces apoptosis to give potent anticancer activity. A series of thiourea B13 analogues was evaluated for their in vitro cytotoxic activities... -
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- A model for the reaction mechanism of the transglutaminase 3 enzyme
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Ahvazi B, Steinert P
- KMID: 1109310
- Exp Mol Med.
- 2003 Aug;35(4):228-242.
Transglutaminase enzymes (TGases) catalyze the calcium dependent formation of an isopeptide bond between protein-bound glutamine and lysine substrates. Previously we have shown that activated TGase 3 acquires two additional calcium... -
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- Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate Cancer
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Hwang YJ, Chung ML, Sohn UD, Im C
- KMID: 2285479
- Korean J Physiol Pharmacol.
- 2013 Dec;17(6):517-523.
- doi: 10.4196/kjpp.2013.17.6.517
Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These... -
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- Molecular pharmacological interaction of phenylbutazone to human neutrophil elastase
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Kang K
- KMID: 1849847
- Korean J Physiol Pharmacol.
- 1998 Jun;2(3):385-393.
Human neutrophil elastase (HNElastase, EC 3.4.21.37), a causative factor of inflammatory diseases, was purified by Ultrogel AcA54 gel filtration and CM-Sephadex ion exchange chromatography. HNElastase was inhibited by phenylbutazone in a concentration dependent... -
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- Development of semi-empirical model for radiochemical reactions
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Lee RJ, Suh HS
- KMID: 1129898
- J Korean Med Sci.
- 2001 Jun;16(3):283-289.
- doi: 10.3346/jkms.2001.16.3.283
A mathematical model, which represents the radio-chemical reactions in water, was developed to study the effect of the radio-chemical products on cell kiling. The five differential equations were solved using... -
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- WNKs: protein kinases with a unique kinase domain
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Huang CL, Cha SK, Wang HR, Xie J, Cobb MH
- KMID: 1090959
- Exp Mol Med.
- 2007 Oct;39(5):565-573.
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in... -
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- Identification and Molecular Characterization of Parkin in Clonorchis sinensis
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Bai X, Kim TI, Lee JY, Dai F, Hong SJ
- KMID: 2381798
- Korean J Parasitol.
- 2015 Feb;53(1):65-75.
- doi: 10.3347/kjp.2015.53.1.65
Clonorchis sinensis habitating in the bile duct of mammals causes clonorchiasis endemic in East Asian countries. Parkin is a RING-between-RING protein and has E3-ubiquitin ligase activity catalyzing ubiquitination and degradation... -
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- Non-syndromic hearing loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 (Connexin 26) gene
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Kim J, Jung J, Lee MG, Choi JY, Lee KA
- KMID: 2155423
- Exp Mol Med.
- 2015 Jun;47(6):e169.
- doi: 10.1038/emm.2015.32
GJB2 alleles containing two cis mutations have been rarely found in non-syndromic hearing loss. Herein, we present a Korean patient with non-syndromic hearing loss caused by the R75Q cis mutation... -
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- Homo-dimerization of RyR1 C-terminus via charged residues in random coils or in an alpha-helix
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Lee EH, Allen PD
- KMID: 1090962
- Exp Mol Med.
- 2007 Oct;39(5):594-602.
To investigate the mechanism by which the C-terminus (4,938-5,037) of the ryanodine receptor 1 (RyR1) homo-tetramerizes, forming a functional Ca2+ -release channel, the structural requirements for the tetramerization were studied... -
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- Molecular characteristics of the inhibition of human neutrophil elastase by nonsteroidal antiinflammatory drugs
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Kang K, Bae SJ, Kim WM, Lee DH, Cho US, Lee MS, Lee MH, Nam SI, Kuettner K, Schwartz D
- KMID: 755079
- Exp Mol Med.
- 2000 Sep;32(3):146-154.
Nonsteroidal antiinflammatory drugs(NSAIDs) are known as clinically effective agents for treatment of inflammatory diseases. Inhibition of cyclooxygenase has been thought to be a major facet of the pharmacological mechanism of... -
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- The N-terminal 1-16 peptide derived in vivo from protein seminal vesicle protein IV modulates alpha-thrombin activity: potential clinical implications
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Lepretti M, Costantini S, Ammirato G, Giuberti G, Caraglia M, Facchiano , Metafora S, Stiuso P
- KMID: 1104808
- Exp Mol Med.
- 2008 Oct;40(5):541-549.
- doi: 10.3858/emm.2008.40.5.541
We have previously shown that seminal vesicle protein IV (SV-IV) and its 1-70 N-terminal fragment have anti-inflammatory activity and modulate anti-thrombin III (AT) activity. Moreover, mass spectrometry analysis of purified... -
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- In Vitro and In Vivo Effect of Parathyroid Hormone Analogue (1-14) Containing alpha-amino-iso-butyric Acid Residue (Aib)1,3
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Rhee Y, Lee W, Lee EJ, Ma S, Park SY, Lim SK
- KMID: 1110745
- Yonsei Med J.
- 2006 Apr;47(2):214-222.
- doi: 10.3349/ymj.2006.47.2.214
Firstly, parathyroid hormone (1-14) [PTH (1-14)] analogue containing various alpha-amino-iso-butyric acid residue (Aib) was synthesized by exchanging the 1st and 3rd Ala residues of alpha carbon of PTH (1-14). This... -
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- Structure-activity relationships of anti-HIV-1 peptides with disulfide linkage between D- and L-cysteine at positions i and i+3, respectively, derived from HIV-1 gp41 C-peptide
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Lee MK, Kim HK, Lee TY, Hahm KS, Kim KL
- KMID: 1105273
- Exp Mol Med.
- 2006 Feb;38(1):18-26.
The constrained alpha-helical structure of a C-peptide is useful for enhancing anti-HIV-1 activity. The i and i+3 positions in an alpha-helical structure are located close together, therefore D-Cys (dC) and... -
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- EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca²⺠and Voltage
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Tak MH, Jang Y, Son WS, Yang YD, Oh U
- KMID: 2468883
- Exp Neurobiol.
- 2019 Dec;28(6):658-669.
- doi: 10.5607/en.2019.28.6.658
Anoctamin1 (ANO1) also known as TMEM16A is a transmembrane protein that functions as a Ca²⺠activated chloride channel. Recently, the structure determination of a fungal Nectria haematococca TMEM16 (nhTMEM16) scramblase... -
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- Atg3-Mediated Lipidation of Atg8 Is Involved in Encystation of Acanthamoeba
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Moon EK, Chung DI, Hong Y, Kong HH
- KMID: 1090608
- Korean J Parasitol.
- 2011 Jun;49(2):103-108.
- doi: 10.3347/kjp.2011.49.2.103
Autophagy is a catabolic process involved in the degradation of a cell's own components for cell growth, development, homeostasis, and the recycling of cellular products. Autophagosome is an essential component... -
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- Magnolol Inhibits LPS-induced NF-kappaB/Rel Activation by Blocking p38 Kinase in Murine Macrophages
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Li MH, Kothandan , Cho SJ, Huong PT, Nan YH, Lee KY, Shin SY, Yea SS, Jeon YJ
- KMID: 2071705
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):353-358.
- doi: 10.4196/kjpp.2010.14.6.353
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-kappaB/Rel in RAW 264.7 cells.... -
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- Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies
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di Luccio
- KMID: 2171336
- J Cancer Prev.
- 2015 Jun;20(2):113-120.
- doi: 10.15430/JCP.2015.20.2.113
BACKGROUND: Multiple myeloma SET domain (MMSET)/nuclear receptor binding SET domain 2 (NSD2) is a lysine histone methyltransferase (HMTase) and bona fide oncoprotein found aberrantly expressed in several cancers, suggesting potential... -
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