- The Role of High Mobility Group Box 1 in Innate Immunity
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Lee SA, Kwak MS, Kim S, Shin JS
- KMID: 1799478
- Yonsei Med J.
- 2014 Sep;55(5):1165-1176.
- doi: 10.3349/ymj.2014.55.5.1165
With growing accounts of inflammatory diseases such as sepsis, greater understanding the immune system and the mechanisms of cellular immunity have become primary objectives in immunology studies. High mobility group... -
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- Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes
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Lee MS
- KMID: 2129596
- J Korean Med Sci.
- 2014 Aug;29(8):1038-1041.
- doi: 10.3346/jkms.2014.29.8.1038
The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important... -
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- Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches
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Park KH, Park WJ
- KMID: 2344144
- J Korean Med Sci.
- 2015 Sep;30(9):1213-1225.
- doi: 10.3346/jkms.2015.30.9.1213
Atherosclerosis is a chronic progressive vascular disease. It starts early in life, has a long asymptomatic phase, and a progression accelerated by various cardiovascular risk factors. The endothelium is an... -
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- Negative regulatory approaches to the attenuation of Toll-like receptor signaling
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Anwar MA, Basith S, Choi S
- KMID: 2154230
- Exp Mol Med.
- 2013 Feb;45(2):e11.
Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is responsible for eradicating invading microorganisms through the induction of inflammatory molecules. These receptors are also involved in... -
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- IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model
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Kim YS, Choi SJ, Choi JP, Jeon SG, Oh SY, Lee BJ, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK
- KMID: 1104380
- Exp Mol Med.
- 2010 Aug;42(8):533-546.
- doi: 10.3858/emm.2010.42.8.054
IL-4 and IL-13 are closely related cytokines that are produced by Th2 cells. However, IL-4 and IL-13 have different effects on the development of asthma phenotypes. Here, we evaluated downstream... -
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- Intrinsic and Extrinsic Regulation of Innate Immune Receptors
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Jeong E, Lee JY
- KMID: 1777009
- Yonsei Med J.
- 2011 May;52(3):379-392.
- doi: 10.3349/ymj.2011.52.3.379
Pattern recognition receptors (PRRs) in innate immune cells play a pivotal role in the first line of host defense system. PRRs recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns... -
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