- The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways
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Shin SY, Lee JH, Min B, Lee YH
- KMID: 1115946
- Exp Mol Med.
- 2006 Dec;38(6):677-685.
The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1 and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated... -
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- Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
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Lee YS, Lan Tran H, Van Ta Q
- KMID: 1088601
- Exp Mol Med.
- 2009 Apr;41(4):259-268.
- doi: 10.3858/emm.2009.41.4.029
Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt... -
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- Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species
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Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK
- KMID: 1025163
- Exp Mol Med.
- 2011 Nov;43(11):605-612.
- doi: 10.3858/emm.2011.43.11.067
Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen... -
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- JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains
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Cho IH, Lee KW, Ha HY, Han PL
- KMID: 1022121
- Exp Mol Med.
- 2011 Aug;43(8):462-470.
- doi: 10.3858/emm.2011.43.8.052
We previously reported that mice lacking JSAP1 (jsap1-/-) were lethal and the brain of jsap1-/- at E18.5 exhibited multiple types of developmental defects, which included impaired axon projection of the... -
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- Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury
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Song J, Cho KJ, Cheon SY, Kim SH, Park KA, Lee WT, Lee JE
- KMID: 2154288
- Exp Mol Med.
- 2013 Dec;45(12):e69.
Neural stem cells (NSCs) have been suggested as a groundbreaking solution for stroke patients because they have the potential for self-renewal and differentiation into neurons. The differentiation of NSCs into... -
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- Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration
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Kwon HJ, Hong SK, Yoon WK, Nam KH, Choi IP, Kim DY, Kim HC, Won YS
- KMID: 1705555
- J Vet Sci.
- 2013 Sep;14(3):257-262.
- doi: 10.4142/jvs.2013.14.3.257
Vitamin D3 up-regulated protein 1 (VDUP1) is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1... -
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- Aldosterone Modulates Cell Proliferation and Apoptosis in the Neonatal Rat Heart
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Sohn HJ, Yoo KH, Jang GY, Lee JH, Choi BM, Lee JH, Bae IS, Yim HE, Son CS, Lee JW
- KMID: 1785908
- J Korean Med Sci.
- 2010 Sep;25(9):1296-1304.
- doi: 10.3346/jkms.2010.25.9.1296
In the present study, we investigated whether and how the mineralocorticoid receptor antagonist spironolactone affects cardiac growth and development through apoptosis and cell proliferation in the neonatal rat heart. Newborn... -
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