- Bisphenol A Impairs Mitochondrial Function in the Liver at Doses below the No Observed Adverse Effect Level
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Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ
- KMID: 1421617
- J Korean Med Sci.
- 2012 Jun;27(6):644-652.
- doi: 10.3346/jkms.2012.27.6.644
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial... -
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- A Case of Simultaneously Occurred Amiodarone-induced Hepatitis and Hypothyroidism
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Cho YS, Han JH, Chae HB, Kim JS, Kang KM, Park SM, Lim JC
- KMID: 1711281
- Korean J Gastroenterol.
- 2013 Jul;62(1):59-63.
- doi: 10.4166/kjg.2013.62.1.59
Amiodarone is a di-iodated benzofuran derivative that is commonly used to treat patients with various cardiac arrhythmias. It is associated with side effects that involve the liver, thyroid, and other... -
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- Suppression of ROS generation by 4,4'-diaminodiphenylsulfone in non-phagocytic human diploid fibroblasts
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Cho SC, Rhim JH, Son YH, Lee SJ, Park SC
- KMID: 946655
- Exp Mol Med.
- 2010 Mar;42(3):223-232.
- doi: 10.3858/emm.2010.42.3.024
The action mode of 4,4'-diaminodiphenylsulfone (DDS) is still under debate, although it has long been used in treatment of several dermatologic diseases including Hansen's disease. In this study, we tested... -
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- Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells
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Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Lee SR, Ko TH, Youm JB, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2154269
- Exp Mol Med.
- 2013 Oct;45(10):e50.
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a... -
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- The role of mitochondrial DNA mutation on neurodegenerative diseases
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Cha MY, Kim DK, Mook-Jung
- KMID: 2155415
- Exp Mol Med.
- 2015 Mar;47(3):e150.
- doi: 10.1038/emm.2014.122
Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may... -
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- Cellular Toxicity of Surfactants Used as Herbicide Additives
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Song HY, Kim YH, Seok SJ, Gil HW, Yang JO, Lee EY, Hong SY
- KMID: 1792971
- J Korean Med Sci.
- 2012 Jan;27(1):3-9.
- doi: 10.3346/jkms.2012.27.1.3
The cellular toxicities of surfactants, a solvent, and an antifreeze that are included in herbicide formulations were assessed by measuring their effects on membrane integrity, metabolic activity, mitochondrial activity, and... -
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- Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes
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Jeon MJ, Leem J, Ko MS, Jang JE, Park HS, Kim HS, Kim M, Kim EH, Yoo HJ, Lee CH, Park IS, Lee KU, Koh EH
- KMID: 1389736
- Exp Mol Med.
- 2012 Sep;44(9):562-570.
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are considered the key determinants of insulin resistance. Impaired mitochondrial function in obese animals was shown to induce the ER stress response, resulting... -
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- zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells
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Yee SB, Baek SJ, Park HT, Jeong SH, Jeong JH, Kim TH, Kim JM, Jeong BK, Park BS, Kwon TK, Yoon I, Yoo YH
- KMID: 1115941
- Exp Mol Med.
- 2006 Dec;38(6):634-642.
In a preliminary study, we found that benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD- fmk), unlike Boc-aspartyl(OMe)-fluoromethylketone (BocD-fmk), at usual dosage could not prevent genistein-induced apoptosis of p815 mastocytoma cells. This study was undertaken to... -
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- Decreased C-reactive protein induces abnormal vascular structure in a rat model of liver dysfunction induced by bile duct ligation
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Jun JH, Choi JH, Bae SH, Oh SH, Kim GJ
- KMID: 2373138
- Clin Mol Hepatol.
- 2016 Sep;22(3):372-381.
- doi: 10.3350/cmh.2016.0032
BACKGROUND/AIMS: Chronic liver disease leads to liver fibrosis, and although the liver does have a certain regenerative capacity, this disease is associated with dysfunction of the liver vessels. C-reactive protein... -
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