- Lung adenoma development and NK activity in mice treated with multiple carcinogens
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Lee YS, Seo JS, Chung HT, Cho KJ, Jang JJ
- KMID: 1421882
- J Korean Med Sci.
- 1992 Mar;7(1):1-5.
- doi: 10.3346/jkms.1992.7.1.1
A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in... -
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- Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat
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Jang JJ, Cho KJ, Lee YS, Bae JH
- KMID: 1421512
- J Korean Med Sci.
- 1991 Mar;6(1):31-36.
- doi: 10.3346/jkms.1991.6.1.31
The modifying potential of capsaicin (CAP) on lesion development was examined in a rat multiorgan carcinogenesis model. Groups 1 and 2 were treated sequentially with diethylnitrosamine (DEN) (100 mg/kg, ip,... -
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- A study on microangiography of induced breast carcinoma in rats (I)
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Bae SH, Im CK, Choi BI, Yoon CH, Ko KW, Ha SW, Han MC
- KMID: 2462987
- J Korean Radiol Soc.
- 1984 Sep;20(3):366-370.
- doi: 10.3348/jkrs.1984.20.3.366
Microangiography is a very effective method in evaluating morphological changes of small vessels not onlybecause it shows subtle changes in microvasculature but also shows whole length of the vessels. Reccently... -
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- Effect of N-Methyl-N-Nitrosourea on Helicobacter-induced Gastric Carcinogenesis in C57BL/6 Mice
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Lee JY, Kim N, Choi YJ, Nam RH, Choi YJ, Lee S, Choi D, Lee HS, Kim JW, Lee DH
- KMID: 2367576
- J Cancer Prev.
- 2016 Sep;21(3):182-186.
- doi: 10.15430/JCP.2016.21.3.182
BACKGROUND: The aim of this study was to investigate the effect of N-methyl-N-nitrosourea (MNU) treatment followed by chronic Helicobacter pylori SS1 and H. felis colonization on the stomachs of C57BL/6... -
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- Formation of 8-hydroxydeoxyguanine moiety in human bladder cellular DNA by bladder carcinogens
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Lee SW, Kim SW, Chung MH
- KMID: 2036794
- Korean J Urol.
- 1993 Feb;34(1):16-25.
The 8-hydroxydeoxyguanosine (8-OH-dG), DNA adduct produced by oxygen radical-induced hydroxylation of C-8 position of guanine residue is accepted as to cause mutation and associate with carcinogenesis, and there are many... -
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- Expression Profiles of F4/80 and Nestin in Ocular Immune Cells Following Pharmaceutically Induced Retinal Degeneration in Adult Mice
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Ahn SI, Ohn YH, Park TK
- KMID: 2217272
- J Korean Ophthalmol Soc.
- 2013 Jun;54(6):945-953.
- doi: 10.3341/jkos.2013.54.6.945
PURPOSE: To evaluate the expression patterns of F4/80 and nestin in the ciliary body and the optic nerve following N-methyl-N-nitrosourea (NMU)-induced retinal degeneration in adult mice. METHODS: After intraperitoneal injection of... -
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- Early Reversible Changes on ERG in Pharmaceutically Induced Retinal Degeneration in Rats
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Roh KH, Park TK, Ohn YH
- KMID: 2208439
- J Korean Ophthalmol Soc.
- 2006 Jul;47(7):1117-1125.
PURPOSE: To evaluate the early ERG (electroretinogram) changes in N-methyl-N-nitrosourea (MNU)-induced retinal degeneration in rats. METHODS: Thirty-six 6-week-old male rats were injected intraperitoneally with 60mg/kg MNU and divided into 6 groups.... -
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- Nestin Expression in the Adult Mouse Retina with Pharmaceutically Induced Retinal Degeneration
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Moon CH, Cho H, Kim YK, Park TK
- KMID: 2364181
- J Korean Med Sci.
- 2017 Feb;32(2):343-351.
- doi: 10.3346/jkms.2017.32.2.343
The present study investigated the temporal pattern and cellular localization of nestin in the adult mouse retina with pharmaceutically induced retinal degeneration using N-methyl-N-nitrosourea (MNU). After a single intraperitoneal injection... -
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- Chemopreventive effects of garlic and mugwort mixture extract on Helicobacter pylori-associated mouse gastric carcinogenesis
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Youm SY, Kim TW, Shin SK, Jeong HS, Kang JK, Kim TM, Kim KH, Ahn B
- KMID: 1726748
- Korean J Vet Res.
- 2014 Sep;54(3):171-177.
Garlic and mugwort have long been used in traditional medicine to prevent various diseases. Several in vitro studies have reported protective efficacies of garlic and mugwort in cases of gastric... -
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- Morphological and functional evaluation of an animal model for the retinal degeneration induced by N-methyl-N-nitrosourea
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Jeong E, Paik SS, Jung SW, Chun MH, Kim IB
- KMID: 1447445
- Anat Cell Biol.
- 2011 Dec;44(4):314-323.
- doi: 10.5115/acb.2011.44.4.314
The retinal degeneration (RD) is a general cause of blindness. To study its pathophysiology and evaluate the effects of new therapeutic agents before clinical trials, it is essential to establish... -
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- Development of a Post-vitrectomy Injection of N-methyl-N-nitrosourea as a Localized Retinal Degeneration Rabbit Model
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Ahn SM, Ahn J, Cha S, Yun C, Park TK, Goo YS, Kim SW
- KMID: 2439007
- Exp Neurobiol.
- 2019 Feb;28(1):62-73.
- doi: 10.5607/en.2019.28.1.62
Since genetic models for retinal degeneration (RD) in animals larger than rodents have not been firmly established to date, we sought in the present study to develop a new rabbit... -
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