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Fungal Strain Improvement for Cellulase Production Using Repeated and Sequential Mutagenesis

Vu VH, Pham TA, Kim K

A fungal strain producing a high level of cellulase was selected from 320 fungal isolates and identified as Aspergillus sp. This strain was further improved for cellulase production by sequential...
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Enhancement of Adenovirus Type 12 Transformation by N-Methyl-N-Nitro-N-Nitrosoguanidine

Choi SB

  • KMID: 1541352
  • J Korean Soc Virol.
  • 1997 Dec;27(2):257-260.
Adenoviruses are icosahedral virions containing double-stranded linen DNA. They are 70 nm to 90 nm in diameter and capsid is composed of 252 capsomeres. Several members of this group, including...
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Mechanisms of HPV-16-induced Transformation in Human Epithelial Cells in Culture

Lee HS, Yang JH, Park IS

  • KMID: 1890527
  • Korean J Gynecol Oncol Colposc.
  • 1996 Dec;7(4):298-307.
Human epithelial cell line immortalized by Ad12-SV40 hybrid virus was transfected with plasmid containing HPV-16 via calcium-phosphate method. Subsequently, 8 clonal cell lines were obtained after G418 selection. Among these...
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Improvement of Fungal Cellulase Production by Mutation and Optimization of Solid State Fermentation

Vu VH, Pham TA, Kim K

  • KMID: 2312606
  • Mycobiology.
  • 2011 Mar;39(1):20-25.
Spores of Aspergillus sp. SU14 were treated repeatedly and sequentially with Co60 gamma-rays, ultraviolet irradiation, and N-methyl-N'-nitro-N-nitrosoguanidine. One selected mutant strain, Aspergillus sp. SU14-M15, produced cellulase in a yield 2.2-fold...
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Neoplastic Paneth cells in the experimental murine carcinoma of the small intestine

Kim WH, Kim YI

The purpose of this study is to elucidate the participation of Paneth cells in experimentally induced adenocarcinoma of the intestine. The rats were fed with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) dissolved in drinking...
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Ossification of the N-methyl-N'-nitro-N-nitrosoguanidine-induced small intestine adenocarcinomas in rats

Kim WH, Kim YI

Eighty rats out of 233 developed malignant tumors in the stomach and small intestine by administration of 100 micrograms/ml N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in drinking water for 28 weeks. Fifteen lesions (30%)...
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Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death

Seok JH, Park KA, Byun HS, Won M, Shin S, Choi BL, Lee H, Kim YR, Hong JH, Park J, Hur GM

Activation of c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is an important cellular response that modulates the outcome of the cells which are exposed to...
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Expression of protein kinase C isoforms in chemical carcinogen-induced neoplastic transformation of human EPITHELIAL cells

Byeon KJ, Hong LW, Kim CS

  • KMID: 2004981
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2001 Jul;23(4):295-305.
Protein kinase C (PKC) is known to play a pivotal role in neoplastic transformation cells and its high expression is often found in a variety of types of tumors including...
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Carcinogenesis of Murine Astrocytes in Culture

Choi GW, Kim MC, Chung H, Lee SP, Yeo HT, Cho SH

  • KMID: 2188359
  • J Korean Neurosurg Soc.
  • 1999 Mar;28(3):300-309.
Astrocytes play important roles in normal brain development and the physiological processes. In particular, 30% of the brain volume consists of astrocytes, and they are the primary target cell in...
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