- Functional Profiling of Human MeCP2 by Automated Data Comparison Analysis and Computerized Expression Pathway Modeling
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Kim I, Lee SH, Jeong J, Park JH, Yoo MA, Kim CM
- KMID: 2166950
- Healthc Inform Res.
- 2016 Apr;22(2):120-128.
- doi: 10.4258/hir.2016.22.2.120
OBJECTIVES: Methyl-CpG binding protein 2 (MeCP2) is a ubiquitous epigenetic factor that represses gene expression by modifying chromatin. Mutations in the MeCP2 gene cause Rett syndrome, a progressive neurodevelopmental disorder.... -
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- Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells
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Ko HM, Jin Y, Park HH, Lee JH, Jung SH, Choi SY, Lee SH, Shin CY
- KMID: 2430090
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):679-688.
- doi: 10.4196/kjpp.2018.22.6.679
Autism spectrum disorders (ASDs) are neurodevelopmental disorders that share behavioral features, the results of numerous studies have suggested that the underlying causes of ASDs are multifactorial. Behavioral and/or neurobiological analyses... -
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- The Modulation of Neurotrophin and Epigenetic Regulators: Implication for Astrocyte Proliferation and Neuronal Cell Apoptosis After Spinal Cord Injury
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Kim JH, Kim SH, Cho SR, Lee JY, Kim JH, Baek A, Jung HS
- KMID: 2356640
- Ann Rehabil Med.
- 2016 Aug;40(4):559-567.
- doi: 10.5535/arm.2016.40.4.559
OBJECTIVE: To investigate alterations in the expression of the main regulators of neuronal survival and death related to astrocytes and neuronal cells in the brain in a mouse model of... -
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- Genetic and Epileptic Features in Rett Syndrome
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Kim HJ, Kim SH, Kim HD, Lee JS, Lee YM, Koo KY, Lee JS, Kang HC
- KMID: 1776982
- Yonsei Med J.
- 2012 May;53(3):495-500.
- doi: 10.3349/ymj.2012.53.3.495
PURPOSE: Rett syndrome is a severe neurodevelopmental disorder in females. Most have mutations in the methyl-CpG-binding protein 2 (MECP2) gene (80-90%). Epilepsy is a significant commonly accompanied feature in Rett... -
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- Diagnostic mutational analysis of MECP2 in Korean patients with Rett syndrome
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Kim IJ, Kim YJ, Son BH, Nam SO, Kang HC, Kim HD, Yoo MA, Choi OH, Kim CM
- KMID: 1111404
- Exp Mol Med.
- 2006 Apr;38(2):119-125.
Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder affecting 1 per 10,000- 15,000 female births worldwide. The disease-causing gene has been identified as MECP2 (methyl- CpG-binding protein 2). In... -
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