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Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage

Ji AR, Ku SY, Cho MS, Kim YY, Kim YJ, Oh SK, Kim SH, Moon SY, Choi YM

Recently, reactive oxygen species (ROS) have been studied as a regulator of differentiation into specific cell types in embryonic stem cells (ESCs). However, ROS role in human ESCs (hESCs) is...
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TGF-betas Synthesized by RPE Cells Have Autocrine Activity on Mesenchymal Transformation and Cell Proliferation

Lee SC, Kim SH, Koh HJ, Kwon OW

The present study investigated the effects of transforming growth factor (TGF)-beta on retinal pigment epithelial (RPE) transformation in a simplified model and also whether or not TGF-beta exhibits similar proliferation...
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Cyclooxygenase-2 Expression Is Related to the Epithelial-to-Mesenchymal Transition in Human Colon Cancers

Jang TJ, Jeon KH, Jung KH

PURPOSE: Down-regulation of E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT). EMT progression in cancer cells is associated with the loss of certain epithelial markers and the acquisition of...
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Interaction of Mesenchymal Stem Cells and Osteoblasts for in vitro Osteogenesis

Kim H, Lee JH, Suh H

It has recently been reported that bone marrow-derived mesenchymal stem cells (MSCs), which are systemically administrated to different species, undergo site-specific differentiation. This suggests that the tissue specific cells may...
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