- Aldosterone-induced TGF-beta1 Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells
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Han JS, Cho BS, Yang CW, Kim YS
- KMID: 1778162
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S195-S203.
- doi: 10.3346/jkms.2009.24.S1.S195
Aldosterone has been shown to stimulate renal TGF-beta1 expression. However, the mechanisms for aldosterone-induced TGF-beta1 expression have not been clearly determined in mesangial cells. We examined the role of extracellular-signal... -
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- Toll-Like Receptor 4 Signaling is Involved in IgA-Stimulated Mesangial Cell Activation
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Lim BJ, Lee D, Hong SW, Jeong HJ
- KMID: 1727993
- Yonsei Med J.
- 2011 Jul;52(4):610-615.
- doi: 10.3349/ymj.2011.52.4.610
PURPOSE: Deposition of polymeric IgA1 in the kidney mesangium is the hallmark of IgA nephropathy, but the molecular mechanisms of IgA-mediated mesangial responses and inflammatory injuries remain poorly understood. We... -
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- The Inhibitory Effect of siRNAs on The High Glucose-Induced Overexpression of TGF-beta1 in Mesangial Cells
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Noh HJ, Kim HC, Lee SS, Kang YN, Chae YM, Park KK
- KMID: 1778423
- J Korean Med Sci.
- 2006 Jun;21(3):430-435.
- doi: 10.3346/jkms.2006.21.3.430
Diabetic nephropathy is characterized by an expansion of the glomerular mesangium, caused by mesangial cell proliferation and an excessive accumulation of extracellar matrix (ECM) proteins, which eventually leading to glomerulosclerosis.... -
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- All-Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy
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Kim CS, Park JS, Ahn CW, Kim KR
- KMID: 2345888
- Yonsei Med J.
- 2015 Nov;56(6):1597-1603.
- doi: 10.3349/ymj.2015.56.6.1597
PURPOSE: The aim of this study was to examine the effects of all-trans retinoic acid (ATRA) on diabetic nephropathy. MATERIALS AND METHODS: We measured amounts of urinary albumin excretion (UAE) after... -
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