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Molecules and their functions in autophagy

Pyo JO, Nah J, Jung YK

Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved...
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Brain site-specific proteome changes in aging-related dementia

Manavalan , Mishra M, Feng L, Sze SK, Akatsu H, Heese K

  • KMID: 2154258
  • Exp Mol Med.
  • 2013 Sep;45(9):e39.
This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer's disease (AD)). Our study...
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Isolation, in vitro propagation, genetic analysis, and immunogenic characterization of an Ehrlichia canis strain from southeastern Brazil

Alves RN, Rieck SE, Ueira-Vieira C, Labruna MB, Beletti ME

Amplification of the 16S rRNA gene from a blood sample obtained from a dog in southeastern Brazil was used to confirm a naturally acquired Ehrlichia (E.) canis infection. Following isolation...
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The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats

Kim SH, Jang YW, Hwang P, Kim HJ, Han GY, Kim CW

Diabetic nephropathy (DN) is a progressive kidney disease that is caused by injury to kidney glomeruli. Podocytes are glomerular epithelial cells and play critical roles in the glomerular filtration barrier....
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Atrophy of brown adipocytes in the adult mouse causes transformation into white adipocyte-like cells

Kim DW, Kim BS, Kwon HS, Kim CG, Lee HW, Choi WH, Kim CG

  • KMID: 1119333
  • Exp Mol Med.
  • 2003 Dec;35(6):518-526.
Adipose tissue is an important endocrine regulator of glucose metabolism and energy homeostasis. Researches have focused on this tissue not only as a target for pharmacotherapy of obesity and insulin...
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