- Effects of Capsaicin Pretreatment on Lung Colonization of B16 Melanoma and mRNA Expressions for Some Cytokines in Mice
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Ha HJ, Park JS, Ha DY
- KMID: 1573066
- Korean J Immunol.
- 2000 Sep;22(3):123-130.
No abstract available. -
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- The Effect of 5% Imiquimod Cream on C57BL/6 Mouse Melanoma Growth
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In SG, Lee JR, Shin JH, Choi GS
- KMID: 2249361
- Korean J Dermatol.
- 2005 Oct;43(10):1332-1336.
BACKGOUND: Imiquimod enhances both acquired and innate immune responses by inducing the synthesis of IFN-alpha and other cytokines (TNF-alpha, IL-1, 6, 8, 12, GM-CSF). Imiguimod was investigated in relation to... -
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- Prolonged ERK Activation of S1P on B16 Melanoma Cells
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Lee HS, Choi GS, Shin JH
- KMID: 2248133
- Korean J Dermatol.
- 2008 Jun;46(6):769-775.
BACKGROUND: The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), was reported to induce apoptosis of some cancer cells and neurons, although it is generally known to exert mitogenic and antiapoptotic effects.... -
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- Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment
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Cho DH, Bae CD, Juhnn YS
- KMID: 755106
- Exp Mol Med.
- 2000 Dec;32(4):235-242.
The terminal differentiation of malignant melanoma cells is known to be induced by activating cAMP signaling pathway with alpha-MSH or cAMP analogues. However, sustained activation of cAMP signaling... -
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- Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway
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Shin DH, Kim OH, Jun HS, Kang MK
- KMID: 1104802
- Exp Mol Med.
- 2008 Oct;40(5):486-494.
- doi: 10.3858/emm.2008.40.5.486
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient of red pepper, has been reported to possess anti-carcinogenic and anti-mutagenic activities. In this study, the anti-migration activity of capsaicin on highly metastatic B16-F10... -
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- Relationship between Melanogenicity and Malignancy in Malignant Melanoma Cells
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Kim HI, Youn JK, Park YK
- KMID: 1729569
- Yonsei Med J.
- 1988 Dec;29(4):357-366.
- doi: 10.3349/ymj.1988.29.4.357
Though the malignancy of a tumor is generally postulated to be affected by the degree of differentiation of tumor cells, the relationship between differentiation and malignancy of tumors has... -
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- Stimulation of melanogenesis by glycyrrhizin in B16 melanoma cells
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Jung GD, Yang JY, Song ES, Park JW
- KMID: 938876
- Exp Mol Med.
- 2001 Sep;33(3):131-135.
Glycyrrhizin (GR), triterpenoid saponin composed of one glycyrrhetinic acid (GA) and two glucuronic acids, is a main constituent of the hydrophilic fraction of licorice (Glycyrrhiza glabra) extracts and is known... -
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- The Motile Properties of Vimentin Intermediate Filament in B16 Melanoma Cells
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Yoon KH, Ha SW, Kang HY, Lee ES, Kang WH
- KMID: 1619872
- Korean J Dermatol.
- 2003 Mar;41(3):293-301.
BACKGROUND: Intermediate filaments as well as microtubule and microfilament are major components of cytoskeleton of human cells. Melanocytes have vimentin intermediate filament, which have not been well investigated as other... -
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- Antioxidative Activity and Anti-melanogenic Effect of the Extract from the Leaves of Robinia Pseudo-acacia L
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Chung JS, Jin GH, Park YK
- KMID: 2359718
- Ann Dermatol.
- 1999 Jul;11(3):142-146.
- doi: 10.5021/ad.1999.11.3.142
BACKGROUND: Plant extracts have been widely used as important therapeutic drugs for many centuries all over the world. There have been many reports that natural products have various kinds of... -
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- Effect of Adenosine on Melanogenesis in B16 Cells and Zebrafish
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Kim MY, Lee HE, Im M, Lee Y, Kim CD, Lee JH, Seo YJ
- KMID: 2171657
- Ann Dermatol.
- 2014 Apr;26(2):209-213.
- doi: 10.5021/ad.2014.26.2.209
BACKGROUND: Adenosine is a nucleoside, in which an adenine molecule is attached to a ribofuranose sugar moiety. It can be released into the microenvironment by metabolically active cells, and then... -
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- Downregulation of NFAT2 promotes melanogenesis in B16 melanoma cells
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Lee YS, Kim DW, Kim S, Choi HI, Lee Y, Kim CD, Lee JH, Lee SD, Lee YH
- KMID: 1455344
- Anat Cell Biol.
- 2010 Dec;43(4):303-309.
- doi: 10.5115/acb.2010.43.4.303
Nuclear factor of activated T-cells (NFAT) proteins are, calcium-regulated transcription factors, key regulator of stimulation-dependent gene activation. In our microarray analysis for the genes expressed in human black and white... -
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- Effect of Hypoxia on the Melanogenesis of Murine B16 Melanoma Cells
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Song YG, Yang JY, Koo JH, Yoon HY, Lee SY, Yun SK, Park BH, Kim HU, Park JW
- KMID: 1931112
- Korean J Dermatol.
- 2007 Apr;45(4):332-337.
BACKGROUND: Numerous reports suggest the role of oxygen in melanogenesis. However, little has been reported on the effect of a hypoxic environment on cellular melanogenesis. OBJECTIVE: The effect of low oxygen... -
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- Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression
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Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY, Chun KH
- KMID: 1383801
- Exp Mol Med.
- 2012 Jun;44(6):387-393.
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, the underlying molecular mechanisms remain largely unknown. In this study, we investigated the effect and possible mechanism... -
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- Anti-melanogenesis and Anti-inflammatory Effects of Cinnamomi Cortex Extract In Vitro
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Park JH, Park SJ, Park KY, Kim BJ
- KMID: 2465952
- Korean J Dermatol.
- 2019 Sep;57(8):448-456.
BACKGROUND: Many researchers have sought to identify safe, natural herbal extracts that exert an anti-melanogenesis effect. Cinnamomi cortex has been widely used as a herbal medicine in Asia and Europe. OBJECTIVE:... -
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- Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination
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Kim A, Noh YW, Kim KD, Jang YS, Choe YK, Lim JS
- KMID: 1123764
- Exp Mol Med.
- 2004 Oct;36(5):428-443.
Immunization with dendritic cells (DCs) pulsed with tumor antigen can activate tumor-specific cytotoxic T lymphocytes (CTL), which is responsible for tumor protection and regression. In this study, we examined whether... -
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- Intratumoral Administration of Secondary Lymphoid Chemokine and Unmethylated Cytosine-phosphorothioate-guanine Oligodeoxynucleotide Synergistically Inhibits Tumor Growth in Vivo
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Oh SM, Oh K, Lee DS
- KMID: 1785982
- J Korean Med Sci.
- 2011 Oct;26(10):1270-1276.
- doi: 10.3346/jkms.2011.26.10.1270
Secondary lymphoid tissue chemokine (SLC), which is expressed in T cell zones of secondary lymphoid organs, including the spleen and lymph nodes, strongly recruits both T lymphocytes and mature dendritic... -
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- Delayed allograft rejection by the suppression of class II transactivator
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Kim TW, Choi YM, Seo JN, Kim JH, Suh YH, Chung DH, Jung KC, Oh KI
- KMID: 1094146
- Exp Mol Med.
- 2006 Jun;38(3):210-216.
We examined the effect of class II transactivator (CIITA) down-modulation on allograft rejection. To inhibit the function of CIITA, we constructed a series of CIITA mutants and found one exhibiting... -
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- Glyceollins, a novel class of soybean phytoalexins, inhibit SCF-induced melanogenesis through attenuation of SCF/c-kit downstream signaling pathways
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Shin SH, Lee YM
- KMID: 2154236
- Exp Mol Med.
- 2013 Apr;45(4):e17.
The anti-melanogenesis effect of glyceollins was examined by melanin synthesis, tyrosinase activity assay in zebrafish embryos and in B16F10 melanoma cells. When developing zebrafish embryos were treated with glyceollins, pigmentation... -
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- Effect of xanthohumol on melanogenesis in B16 melanoma cells
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Koo JH, Kim HT, Yoon HY, Kwon KB, Choi IW, Jung SH, Kim HU, Park BH, Park JW
- KMID: 756333
- Exp Mol Med.
- 2008 Jun;40(3):313-319.
- doi: 10.3858/emm.2008.40.3.313
Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin... -
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- Antitumor immunity induced by tumor cells engineered to express a membrane-bound form of IL-2
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Chang MR, Lee WH, Choi JW, Park SO, Paik SG, Kim YS
- KMID: 1056237
- Exp Mol Med.
- 2005 Jun;37(3):240-249.
Transduction of cytokine gene into tumor cells is a promising method of tumor therapy, but the value is limited by accompanying side effects. To focus antitumor immune response to tumor... -
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