- The Challenge of Designing Stroke Trials That Change Practice: MCID vs. Sample Size and Pragmatism
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Goyal M, McDonough R, Fisher M, Ospel J
- KMID: 2525330
- J Stroke.
- 2022 Jan;24(1):49-56.
- doi: 10.5853/jos.2021.02740
Randomized controlled trials (RCT) are the basis for evidence-based acute stroke care. For an RCT to change practice, its results have to be statistically significant and clinically meaningful. While methods... -
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- Infarcts Due to Large Vessel Occlusions Continue to Grow Despite Near-Complete Reperfusion After Endovascular Treatment
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Ospel JM, Rex N, Oueidat K, McDonough R, Rinkel L, Baird G, Collins S, Jindal G, Alvin MD, Boxerman J, Barber P, Jayaraman M, Smith W, Amirault-Capuano A, Hill MD, Goyal M, McTaggart R
- KMID: 2556046
- J Stroke.
- 2024 May;26(2):260-268.
- doi: 10.5853/jos.2023.02621
Background and Purpose Infarcts in acute ischemic stroke (AIS) patients may continue to grow even after reperfusion, due to mechanisms such as microvascular obstruction and reperfusion injury. We investigated whether... -
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