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Macrophage Activation Syndrome as the Extreme Form of Kawasaki Disease

Park HJ, Cho YJ, Bae EY, Choi UY, Lee SY, Jeong DC, Lee KY, Kang JH

  • KMID: 2072435
  • Korean J Pediatr Infect Dis.
  • 2010 Dec;17(2):177-181.
Few cases of macrophage activation syndrome (MAS) or reactive hemophagocytic lymphohistiocytosis (HLH) during the acute febrile phase of Kawasaki disease (KD) have been reported. We report on a case of...
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A Case of Macrophage Activation Syndrome Developed in Female Adolescent with Systemic Lupus Erythematosus

Keum SW, Kim MJ, Bae EY, Han SB, Chung NG, Jeong DC, Kang JH

Macrophage activation syndrome (MAS) is a severe complication in patients with autoimmune disease. We should consider MAS in patients with autoimmune disease, who present with newly developed fever, and MAS...
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Tocilizumab-induced Transaminitis in a Seropositive Rheumatoid Arthritis Patient with Macrophage Activation Syndrome

Yoo BW, Park CK, Yun HR, Kim D, Lee SK, Lee SW

As a new humanized monoclonal antibody against the interleukin-6 receptor, tocilizumab is currently used for the treatment of rheumatoid arthritis (RA) patients. Tocilizumab was reported to provoke drug-related liver toxicity,...
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Refractory Macrophage Activation Syndrome in a Patient with Systemic Lupus Erythematosus Treated with Tocilizumab

Oh JS, Park J, Lee NK, Bae SH, Kim YG, Lee CK, Yoo B

Macrophage activation syndrome (MAS) is a secondary hemophagocytic lymphohistiocytosis caused by autoimmune diseases, such as systemic lupus erythematosus (SLE). It is characterized by fever, cytopenia, coagulopathy, hepatosplenomegaly, elevated liver enzyme,...
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A Case of Macropharge Activation Syndrome Successfully Treated with Combination Therapy Including Etanercept

Sim YS, Kim HS, Kim KN

Macrophage activation syndrome (MAS) is a severe, potentially life-threatening complication of childhood systemic inflammatory disorder, primarily systemic onset juvenile rheumatoid arthritis (SoJRA). It is characterized by pancytopenia, liver insufficiency, coagulopathy,...
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Macrophage Activation Syndrome Triggered by Herpes Viral Infection as the Presenting Manifestation of Juvenile Systemic Lupus Erythematosus

Noh JH, Jeong DY, Jeon IS, Kim HM

Macrophage activation syndrome (MAS) is a rare complication in systemic lupus erythematosus (SLE) that can be triggered by infections. Due to the fact that MAS may mimic clinical features of...
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Hemophagocytic Lymphohistiocytosis in Adults: Overview, Diagnosis, and Treatment

Kim DY

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome involving defective apoptosis in which the pathways regulating the termination of immune and inflammatory responses are disrupted. Fever, cytopenia, splenomegaly, and hemophagocytosis are typical...
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Recurrent macrophage activation syndrome since toddler age in an adolescent boy with HLA B27 positive juvenile ankylosing spondylitis

Park JH, Seo YM, Han SB, Kim KH, Rhim JW, Chung NG, Kim MS, Kang JH, Jeong DC

Recurrent macrophage activation syndrome (MAS) is very rare. We present the case of an adolescent boy with human leukocyte antigen (HLA) B27-positive ankylosing spondylitis (AS), who experienced episodes of recurrent...
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