- Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination
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Kim A, Noh YW, Kim KD, Jang YS, Choe YK, Lim JS
- KMID: 1123764
- Exp Mol Med.
- 2004 Oct;36(5):428-443.
Immunization with dendritic cells (DCs) pulsed with tumor antigen can activate tumor-specific cytotoxic T lymphocytes (CTL), which is responsible for tumor protection and regression. In this study, we examined whether... -
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- Antibody Response of Mouse Splenocytes Using Mixture of Supernatants of Thymocytes, Adherent and Non-adherent Splenocytes: In-vitro Immunization-II
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Kim D, Noh GW, Kim DH, Kwon OH
- KMID: 1421475
- J Korean Med Sci.
- 1990 Mar;5(1):25-31.
- doi: 10.3346/jkms.1990.5.1.25
We adapted one of the in-vitro immunization methods to induce antibody responses and confirmed the success of the immunization by enzyme-linked immunosorbent assay (ELISA) without hybridization. We have previously reported... -
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- Subdominant H60 antigen-specific CD8 T-cell response precedes dominant H4 antigen-specific response during the initial phase of allogenic skin graft rejection
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Yoo KI, Jeon JY, Ryu SJ, Nam G, Youn H, Choi EY
- KMID: 2155405
- Exp Mol Med.
- 2015 Feb;47(2):e140.
- doi: 10.1038/emm.2014.107
In allogeneic transplantation, including the B6 anti-BALB.B settings, H60 and H4 are two representative dominant minor histocompatibility antigens that induce strong CD8 T-cell responses. With different distribution patterns, H60 expression... -
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- Two-signal blockade with anti-CD45RB and anti-CD154 monoclonal antibodies inhibits graft rejection via CD4-dependent mechanisms in allogeneic skin transplantation
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Kim EY, Lee EN, Lee J, Park HJ, Chang CY, Jung DY, Choi SY, Lee SK, Joh JW, Kim SJ
- KMID: 1094154
- Exp Mol Med.
- 2006 Jun;38(3):284-294.
Blockade of signal 1 or 2 for T-cell activation by the use of anti-CD45RB and anti-CD154 monoclonal antibodies (mAb) (two-signal blockade) has been proven effective in preventing or delaying graft... -
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- Effects of Cytokine Milieu Secreted by BCG-treated Dendritic Cells on Allergen-Specific Th Immune Response
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Koh YI, Choi IS, Lee JJ
- KMID: 1733501
- J Korean Med Sci.
- 2004 Oct;19(5):640-646.
- doi: 10.3346/jkms.2004.19.5.640
Bacillus Calmette-Guerin (BCG) is reported to suppress Th2 response and asthmatic reaction. Dendritic cells (DCs), the major antigen-presenting cells, infections with BCG are known to result in inducing various cytokines.... -
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- Effects of cyclosporin A treatment on the pathogenesis of avian leukosis virus subgroup J infection in broiler chickens with Marek's disease virus exposure
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Kim Y, Brown TP, Pantin-Jackwood MJ
- KMID: 1089605
- J Vet Sci.
- 2003 Dec;4(3):245-255.
In this study, we investigated the effects of T-cell suppression on the pathogenesis of subgroup J avian leukosis virus (ALV-J). Chickens were treated with cyclosporin A (CSP) 50 mg/Kg body... -
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- Involvement of tumor necrosis factor receptor superfamily (TNFRSF) members in the pathogenesis of inflammatory diseases
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Kwon B, Kim BS, Cho HR, Park JE, Kwon BS
- KMID: 1088652
- Exp Mol Med.
- 2003 Feb;35(1):8-16.
Current therapies for autoimmune diseases are not cures but merely palliatives, aimed at reducing symptoms. For the most part, these treatments provide nonspecific suppression of the immune system and thus... -
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- Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen
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Chang BS, Bohach GA, Lee SU, Davis WC, Fox LK, Ferens WA, Seo KS, Koo HC, Kwon NH, Park YH
- KMID: 1091208
- J Vet Sci.
- 2005 Sep;6(3):247-250.
Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be... -
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- Understanding of molecular mechanisms in natural killer cell therapy
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Yoon SR, Kim TD, Choi I
- KMID: 2155406
- Exp Mol Med.
- 2015 Feb;47(2):e141.
- doi: 10.1038/emm.2014.114
Cancer cells and the immune system are closely related and thus influence each other. Although immune cells can suppress cancer cell growth, cancer cells can evade immune cell attack via... -
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- Introduction of the CIITA gene into tumor cells produces exosomes with enhanced anti-tumor effects
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Lee YS, Kim SH, Cho JA, Kim CW
- KMID: 1009967
- Exp Mol Med.
- 2011 May;43(5):281-290.
- doi: 10.3858/emm.2011.43.5.029
Exosomes are small membrane vesicles secreted from various types of cells. Tumor-derived exosomes contain MHC class I molecules and tumor-specific antigens, receiving attention as a potential cancer vaccine. For induction... -
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