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The Role of Upper Airway Microbiome in the Development of Adult Asthma

Losol P, Choi JP, Kim SH, Chang YS

Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper...
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Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma

Pham DL, Kim SH, Losol P, Yang EM, Shin YS, Ye YM, Park HS

BACKGROUND/AIMS: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic...
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Molecular Genetic Mechanisms of Chronic Urticaria

Losol P, Yoo HS, Park HS

Chronic urticaria (CU) is a common allergic skin disease that requires long-term pharmacological treatment. Some patients with severe CU suffer a poor quality of life. Although the pathogenic mechanisms of...
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IL-5 Promoter Polymorphism Enhances IgE Responses to Staphylococcal Superantigens in Adult Asthmatics

Losol P, Kim SH, Hwang EK, Shin YS, Park HS

Interleukin 5 (IL-5) is a key cytokine involved in the induction of T-helper type 2 (Th2) responses in the asthmatic airway. We investigated IL-5 genetic polymorphisms associated with asthma phenotypes,...
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A genetic effect of IL-5 receptor alpha polymorphism in patients with aspirin-exacerbated respiratory disease

Losol P, Kim SH, Shin YS, Ye YM, Park HS

  • KMID: 2154233
  • Exp Mol Med.
  • 2013 Mar;45(3):e14.
Persistent eosinophil activation in both the upper and lower airway mucosa is a central feature of aspirin-exacerbated respiratory disease (AERD). Eosinophil activation and survival are profoundly influenced by interleukin 5...
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Role of Toll-like Receptor 3 Variants in Aspirin-Exacerbated Respiratory Disease

Palikhe NS, Kim SH, Kim JH, Losol P, Ye YM, Park HS

PURPOSE: Although the mechanism of virus-induced, aspirin-exacerbated respiratory disease (AERD) is not known fully, direct activation of viral components through Toll-like receptor 3 (TLR3) has been suggested. TLR3 recognizes double-stranded...
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