- Histochemical and Cytogenetical Effects of Insulin on Mouse Liver in vivo and in vitro
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Hahn SS, Kim DS
- KMID: 687761
- Yonsei Med J.
- 1978 Dec;19(2):48-55.
- doi: 10.3349/ymj.1978.19.2.48
Histochemically detectable changes in the liver of the mouse after subcutaneous injection of a single sublethal does of insulin and the effect of insulin on mitotic rate and chromosome changes... -
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- The Expression of E-cadherin in Human and Rat Hepatic Stellate Cells: Evidence of Epithelial-Mesenchymal Transition
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Lim YS, Lee HS
- KMID: 863072
- Korean J Hepatol.
- 2002 Mar;8(1):90-99.
BACKGROUND/AIMS: The embryonal origin of hepatic stellate cells (HSCs), the principal cells in hepatic fibrogenesis, is still intriguing. We have previously demonstrated that human HSCs express cytokeratins which suggests... -
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- A mechanism of differential expression of GLUT2 in hepatocyte and pancreatic beta-cell line
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Kim JW, Kim YK, Ahn YH
- KMID: 754982
- Exp Mol Med.
- 1998 Mar;30(1):15-20.
DNase I footprinting assay using liver nuclear extracts revealed six protected regions between nucleotide -600 and +110 and hence named Box I-VI. Upstream promoter element (UPE), a DNA element playing crucial role... -
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- Transforming growth factor-beta1 protein, proliferation and apoptosis of oval cells in acetylaminofluorene-induced rat liver regeneration
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Park DY, Suh KS
- KMID: 646021
- J Korean Med Sci.
- 1999 Oct;14(5):531-538.
- doi: 10.3346/jkms.1999.14.5.531
Administering of 2-acetylaminofluorene (2-AAF) before a two-thirds partial hepatectomy (PHx) results in suppression of hepatocyte proliferation and stimulation of oval cell proliferation. The objectives of this study was to examine... -
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- Protective Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in Rats
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Park ES, Kim SD, Lee MH, Lee HS, Lee IS, Sung JK, Yoon YS
- KMID: 1089402
- J Vet Sci.
- 2003 Aug;4(2):129-136.
To investigate the neutralizing effect of N-acetylcysteine (NAC) and selenium (Se) aganist doxorubicin (DOX) toxicity in rats, NAC (140 mg/kg, p.o.) and Se (0.5 mg/kg, p.o.) were administered for 2... -
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- Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells
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Kim YS, Jhon DY, Lee KY
- KMID: 1380210
- Exp Mol Med.
- 2004 Apr;36(2):157-164.
Selenium is a dietary essential trace nutrient with important biological roles. Selenocompounds were reported to induce apoptosis in many types of tumor cells. In this study, we investigated the signaling... -
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- C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro
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Kim JW, Ahn YH
- KMID: 755211
- Exp Mol Med.
- 2002 Nov;34(5):379-384.
The expression of the GLUT2 glucose transporter gene in liver is suppressed in cultured hepatoma cell lines and primary cultured hepatocytes. Earlier report showed that CCAAT/enhancer binding protein (C/EBP) regulates... -
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- Chronic liver injury, TGF-beta, and cancer
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Bissell DM
- KMID: 1457528
- Exp Mol Med.
- 2001 Dec;33(4):179-190.
Cells termed myofibroblasts are prominent in the injury response of all epithelial tissues. They exhibit proliferation, migration, production of collagen and other extracellular matrix (ECM) molecules, and contraction, all for... -
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- Oxidative stress effect on the activation of hepatic stellate cells
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Lee KS, Lee SJ, Park HJ, Chung JP, Han KH, Chon CY, Lee SI, Moon YM
- KMID: 720581
- Yonsei Med J.
- 2001 Feb;42(1):1-8.
- doi: 10.3349/ymj.2001.42.1.1
Collagen is the most excessive extracellular matrix protein in hepatic fibrosis. Activated, but not quiescent, hepatic stellate cells (HSCs) have a high level of collagen and a... -
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- A Quantitative Morphologic Analysis of the Rat's Liver in the Postnatal Period
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Pak SY
- KMID: 687667
- Yonsei Med J.
- 1972 Dec;13(1):60-66.
- doi: 10.3349/ymj.1972.13.1.60
Quantitative morphological or histological features within the hepatic acinus were studied to determine the proportional difference of tissue components by regions or zones in different ages in the male albino... -
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- SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury
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Lee KH, Kim SE, Lee YS
- KMID: 1110125
- Exp Mol Med.
- 2006 Aug;38(4):408-416.
c-Jun N-terminal kinase (JNK) is activated during hepatic reperfusion, and JNK inhibitors are known to protect other major organs from ischemia-reperfusion (I/R) injury. We attempted to determine the effect of... -
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- Correlation of changes in natural killer cell activity and glutathione S-transferase placental form positive hepatocytes in diethylnitrosamine-induced rat hepatocarcinogenesis
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Lee YS, Choe GY, Kim YI, Park SH, Park IA, Lee MJ, Jang JJ
- KMID: 648076
- J Korean Med Sci.
- 1999 Apr;14(2):171-174.
- doi: 10.3346/jkms.1999.14.2.171
To evaluate the induction of preneoplastic hepatic foci in relation to natural killer cell (NK) activity, we sequentially analyzed glutathione S-transferase placental form positive (GST-P+) hepatocytes and NK activity during ... -
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- Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis
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Yoon YS, Ryu D, Lee MW, Hong S, Koo SH
- KMID: 1119323
- Exp Mol Med.
- 2009 Aug;41(8):577-583.
- doi: 10.3858/emm.2009.41.8.063
During fasting periods, hepatic glucose production is enhanced by glucagon to provide fuels for other organs. This process is mediated via cAMP-dependent induction of the CREB regulated transcriptional coactivator (CRTC)... -
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- Clinical characteristics of acute viral lower respiratory tract infections in hospitalized children in Seoul, 1996-1998
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Ahn KM, Chung SH, Chung EH, Koh YJ, Nam SY, Kim JH, Son JA, Park JY, Lee NY, Lee SI
- KMID: 1731314
- J Korean Med Sci.
- 1999 Aug;14(4):405-411.
- doi: 10.3346/jkms.1999.14.4.405
This study was performed to investigate the etiologic agents, age distribution, clinical manifestations and seasonal occurrence of acute viral lower respiratory tract infections in children. We confirmed viral etiologies using... -
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- Dedifferentiation of conditionally immortalized hepatocytes with long-term in vitro passage
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Kim BH, Sung SR, Choi EH, Kim YI, Kim KJ, Dong SH, Kim HJ, Chang YW, Lee JI, Chang R
- KMID: 927131
- Exp Mol Med.
- 2000 Mar;32(1):29-37.
The rat hepatocytes were immortalized using a temperature-sensitive mutant of SV40 large T antigen (tsT) to develop as a possible substitute for primary hepatocytes. Four rat hepatocyte lines that have... -
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- Regulation of ATP-citrate lyase gene transcription
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Kim KS, Kang JG, Moon YA, Park SW, Kim YS
- KMID: 699895
- Yonsei Med J.
- 1996 Jun;37(3):214-224.
- doi: 10.3349/ymj.1996.37.3.214
It has been suggested that glucose metabolites and insulin are the most important factors inducing ATP-citrate lyase (ACL) by a high carbohydrate diet. We have used a primary culture of... -
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- Changes in Inward Rectifier K+ Channels in Hepatic Stellate Cells During Primary Culture
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Lee DH, Kong ID, Lee JW, Park KS
- KMID: 724263
- Yonsei Med J.
- 2008 Jun;49(3):459-471.
- doi: 10.3349/ymj.2008.49.3.459
PURPOSE: This study examined the expression and function of inward rectifier K+ channels in cultured rat hepatic stellate cells (HSC). MATERIALS AND METHODS: The expression of inward rectifier K+ channels... -
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- Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients
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Lee M, Lee MA, Lee SK, Son M, Cho SW, Park S, Kim HI
- KMID: 648077
- J Korean Med Sci.
- 1999 Apr;14(2):175-181.
- doi: 10.3346/jkms.1999.14.2.175
The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance. This study was initiated to investigate whether... -
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