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Clinical implications of advances in liver regeneration

Kwon YJ, Lee KG, Choi D

Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better...
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Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

Koo SH

Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the...
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Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms

Park WH, Pak YK

Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various...
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CD44 Disruption Attenuates Murine Hepatic Ischemia/Reperfusion Injury

Kim MS, Lee KH, Lee WM, Jun JH, Kim DH

Neutrophil adhesion and migration are critical in hepatic ischemia/reperfusion (I/R) injury. Despite very strong preclinical data, recent clinical trials failed to show a protective effect of anti-adhesion therapy in reperfusion...
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Bioelectrical Impedance May Predict Cell Viability During Ischemia and Reperfusion in Rat Liver

Cui ML, Ahn HS, Kim JY, Shin HJ, Lee DS, Kim HJ, Yun SS

Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but no method could monitor or predict it real-time during surgery. We measured bioelectrical impedance...
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Tissue-specific activation of mitogen-activated protein kinases for expression of transthyretin by phenylalanine and its metabolite, phenylpyruvic acid

Park JW, Lee MH, Choi JO, Park HY, Jung SC

Phenylketonuria is an autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase. Transthyretin has been implicated as an indicator of nutritional status in phenylketonuria patients. In this study, we...
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Association of Hepatic Iron Deposition and Serum Iron Indices with Hepatic Inflammation and Fibrosis Stage in Nonalcoholic Fatty Liver Disease

Moon JH, Park SH, Oh KC, Jung JO, Shin WG, Kim JP, Kim KO, Park CH, Hahn T, Yoo KS, Kim JH, Kim DJ, Lee MS, Park CK, Jun SY

  • KMID: 772970
  • Korean J Gastroenterol.
  • 2006 Jun;47(6):432-439.
BACKGROUND/AIMS: Nonalcoholic steatohepatitis can develop from nonalcoholic fatty liver and progress to severe liver disease such as cirrhosis. The mechanism determining the progression from fatty liver to steatohepatitis is...
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Antioxidant Status in Nonalcoholic Steatohepatitis

Park KS, Jang BK, Kwon KM, Chung WJ, Cho KB, Hwang JS, Ahn SH, Mun KC, Kim YH

  • KMID: 760591
  • Korean J Hepatol.
  • 2005 Jun;11(2):135-143.
BACKGROUND/AIMS: Nonalcoholic steatohepatitis (NASH) is chronic liver disease that can potentially progress to end stage liver disease. Oxidative stress to the vulnerable fatty liver has been reported as a...
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The Effects of Antioxidants and Nitric Oxide Modulators on Hepatic Ischemic-Reperfusion Injury in Rats

Rhee JE, Jung SE, Shin SD, Suh GJ, Noh DY, Youn YK, Oh SK, Choe KJ

Ischemic-reperfusion injury (IRI) is thought to be caused by oxygen radicals. Nitric oxide (NO) also has been thought to play a key role in IRI. This experiment was designed to...
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