- Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
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Koo SH
- KMID: 1705200
- Clin Mol Hepatol.
- 2013 Sep;19(3):210-215.
- doi: 10.3350/cmh.2013.19.3.210
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the... -
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- Bioelectrical Impedance May Predict Cell Viability During Ischemia and Reperfusion in Rat Liver
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Cui ML, Ahn HS, Kim JY, Shin HJ, Lee DS, Kim HJ, Yun SS
- KMID: 1792928
- J Korean Med Sci.
- 2010 Apr;25(4):577-582.
- doi: 10.3346/jkms.2010.25.4.577
Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but no method could monitor or predict it real-time during surgery. We measured bioelectrical impedance... -
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- Clinical implications of advances in liver regeneration
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Kwon YJ, Lee KG, Choi D
- KMID: 2155285
- Clin Mol Hepatol.
- 2015 Mar;21(1):7-13.
- doi: 10.3350/cmh.2015.21.1.7
Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better... -
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- CD44 Disruption Attenuates Murine Hepatic Ischemia/Reperfusion Injury
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Kim MS, Lee KH, Lee WM, Jun JH, Kim DH
- KMID: 1094264
- J Korean Med Sci.
- 2011 Jul;26(7):919-926.
- doi: 10.3346/jkms.2011.26.7.919
Neutrophil adhesion and migration are critical in hepatic ischemia/reperfusion (I/R) injury. Despite very strong preclinical data, recent clinical trials failed to show a protective effect of anti-adhesion therapy in reperfusion... -
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- Association of Hepatic Iron Deposition and Serum Iron Indices with Hepatic Inflammation and Fibrosis Stage in Nonalcoholic Fatty Liver Disease
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Moon JH, Park SH, Oh KC, Jung JO, Shin WG, Kim JP, Kim KO, Park CH, Hahn T, Yoo KS, Kim JH, Kim DJ, Lee MS, Park CK, Jun SY
- KMID: 772970
- Korean J Gastroenterol.
- 2006 Jun;47(6):432-439.
BACKGROUND/AIMS: Nonalcoholic steatohepatitis can develop from nonalcoholic fatty liver and progress to severe liver disease such as cirrhosis. The mechanism determining the progression from fatty liver to steatohepatitis is... -
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- Tissue-specific activation of mitogen-activated protein kinases for expression of transthyretin by phenylalanine and its metabolite, phenylpyruvic acid
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Park JW, Lee MH, Choi JO, Park HY, Jung SC
- KMID: 983983
- Exp Mol Med.
- 2010 Feb;42(2):105-115.
- doi: 10.3858/emm.2010.42.2.012
Phenylketonuria is an autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase. Transthyretin has been implicated as an indicator of nutritional status in phenylketonuria patients. In this study, we... -
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- The Effects of Antioxidants and Nitric Oxide Modulators on Hepatic Ischemic-Reperfusion Injury in Rats
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Rhee JE, Jung SE, Shin SD, Suh GJ, Noh DY, Youn YK, Oh SK, Choe KJ
- KMID: 1109759
- J Korean Med Sci.
- 2002 Aug;17(4):502-506.
- doi: 10.3346/jkms.2002.17.4.502
Ischemic-reperfusion injury (IRI) is thought to be caused by oxygen radicals. Nitric oxide (NO) also has been thought to play a key role in IRI. This experiment was designed to... -
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- Antioxidant Status in Nonalcoholic Steatohepatitis
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Park KS, Jang BK, Kwon KM, Chung WJ, Cho KB, Hwang JS, Ahn SH, Mun KC, Kim YH
- KMID: 760591
- Korean J Hepatol.
- 2005 Jun;11(2):135-143.
BACKGROUND/AIMS: Nonalcoholic steatohepatitis (NASH) is chronic liver disease that can potentially progress to end stage liver disease. Oxidative stress to the vulnerable fatty liver has been reported as a... -
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- Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms
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Park WH, Pak YK
- KMID: 1123369
- Exp Mol Med.
- 2011 Oct;43(10):571-579.
- doi: 10.3858/emm.2011.43.10.064
Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various... -
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