- The Effect of Gromwell (Lithospermum erythrorhizon) Extract on the Stratum Corneum Hydration and Ceramides Content in Atopic Dermatitis Patients
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Cho HR, Cho Y, Kim J, Seo DB, Kim SH, Lee SJ, Kim NI
- KMID: 2172085
- Ann Dermatol.
- 2008 Jun;20(2):56-66.
- doi: 10.5021/ad.2008.20.2.56
BACKGROUND: A disruption of the balance between the water content of the stratum corneum (SC) and skin surface lipids may lead to the clinical manifestation of dryness of skin in... -
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- Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-kappaB
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Prasad RG, Choi YH, Kim GY
- KMID: 2380343
- Biomol Ther.
- 2015 Mar;23(2):110-118.
- doi: 10.4062/biomolther.2015.006
According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysaccharide... -
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- Optimization of Extraction Conditions for Active Compounds of Herbal Medicinal Formula, DF, by Response Surface Methodology
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Jeong B, Choi SY, Jang HS, Yoo G, Kim SH, Kim JH, Kwon YS, Roh JS, Yoon Y, Shin SS, Yang H
- KMID: 2376493
- Nat Prod Sci.
- 2017 Mar;23(1):9-15.
- doi: 10.20307/nps.2017.23.1.9
DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in... -
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- The Inhibitory Effect of Shikonin on the Agonist-Induced Regulation of Vascular Contractility
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Je HD, Kim HD, La HO
- KMID: 2380332
- Biomol Ther.
- 2015 May;23(3):233-237.
- doi: 10.4062/biomolther.2014.148
Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin... -
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- Shikonin Induces Apoptotic Cell Death via Regulation of p53 and Nrf2 in AGS Human Stomach Carcinoma Cells
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Ko H, Kim SJ, Shim SH, Chang H, Ha CH
- KMID: 2351674
- Biomol Ther.
- 2016 Sep;24(5):501-509.
- doi: 10.4062/biomolther.2016.008
Shikonin, which derives from Lithospermum erythrorhizon, has been traditionally used against a variety of diseases, including cancer, in Eastern Asia. Here we determined that shikonin inhibits proliferation of gastric cancer... -
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- A Nudix Hydrolase Protein, Ysa1, Regulates Oxidative Stress Response and Antifungal Drug Susceptibility in Cryptococcus neoformans
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Lee KT, Kwon H, Lee D, Bahn YS
- KMID: 2312723
- Mycobiology.
- 2014 Mar;42(1):52-58.
A nucleoside diphosphate-linked moiety X (Nudix) hydrolase-like gene, YSA1, has been identified as one of the gromwell plant extract-responsive genes in Cryptococcus neoformans. Ysa1 is known to control intracellular concentrations... -
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- Screening of Anti-HIV-1 Activity of Natural Product by MTT Assay
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Lee JS, Nam JG, Kang C, Lee HR, Lee YJ, Shin YO
- KMID: 2204569
- J Korean Soc Virol.
- 1997 Mar;27(1):87-95.
Methanol and/or boiling water extraction of 201 natural products and subsequent MTT assay using MT-4 cell line was carried out to screen the anti-HIV-1 activity. Among 97 methanol extracts, 7... -
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