- Study on the action by PAF on IL-1 modulation in alveolar macrophages: Involvement of endogenous arachidonate metabolites and intracellular Ca++ mobilization
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Lee J, Kim WK, Hah JS
- KMID: 1562327
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):241-249.
Platelet-activating factor (PAF) enhanced interleukin-1 (IL-1) activity by the interaction with a specific receptor in rat alveolar macrophages. In this study, we investigated the role of endogenous arachidonate metabolites and intracellular calcium mobilization... -
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- Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids
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Lee HS, Kim EJ, Oh YS, Cho HJ, Park JH
- KMID: 1804431
- Cancer Res Treat.
- 2001 Oct;33(5):404-413.
PURPOSE: Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of colon cancer is mediated through modulation of eicosanoid... -
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- Benzoxazole Derivative B-98 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis and the Change of T Cell Profiles in Acute Murine Colitis Model
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Song EM, Jung SA, Lee JS, Kim SE, Shim KN, Jung HK, Yoo K, Park HY
- KMID: 1711277
- Korean J Gastroenterol.
- 2013 Jul;62(1):33-41.
- doi: 10.4166/kjg.2013.62.1.33
BACKGROUND/AIMS: The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to... -
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- The role of leukotriene modifier in pediatric allergic disease
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Choi BS, Sohn MH, Kim KE
- KMID: 2218654
- Allergy Asthma Respir Dis.
- 2015 Jul;3(4):255-260.
- doi: 10.4168/aard.2015.3.4.255
Leukotriene (LT) modifiers are composed of leukotriene receptor antagonists and 5-lipoxygenase inhibitors. LTs, C4, D4, and E4 are collectively termed cysteinyl LTs and best are the characterized receptors for cysLTs... -
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- Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties
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Yoon JH, Baek SJ
- KMID: 2158137
- Yonsei Med J.
- 2005 Oct;46(5):585-596.
- doi: 10.3349/ymj.2005.46.5.585
There is persuasive epidemiological and experimental evidence that dietary polyphenols have anti-inflammatory activity. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have long been used to combat inflammation. Recently, cyclooxygenase (COX)... -
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- Regulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo
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Kim SY, Kim TB, Moon KA, Kim TJ, Shin D, Cho YS, Moon HB, Lee KY
- KMID: 1094126
- Exp Mol Med.
- 2008 Aug;40(4):461-476.
- doi: 10.3858/emm.2008.40.4.461
Reactive oxygen species (ROS) performs a pivotal function as a signaling mediator in receptor-mediated signaling. However, the sources of ROS in this signaling have yet to be determined, but may... -
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