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A Disintegrin and Metalloprotease with Thrombospondin Motif 2 May Contribute to Cirrhosis in Humans through the Transforming Growth Factor-beta/SMAD Pathway

Dong C, Li HJ, Chang S, Liao HJ, Zhang ZP, Huang P, Tang HH

  • KMID: 2135073
  • Gut Liver.
  • 2013 Mar;7(2):213-220.
BACKGROUND/AIMS: We aimed to investigate the correlation between a disintegrin and metalloprotease with thrombospondin motif 2 (ADAMTS-2) and transforming growth factor-beta1 (TGF-beta1) in clinical human cirrhotic tissues. METHODS: The liver tissues...
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Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation

Tsai YC, Cheng TS, Liao HJ, Chuang MH, Chen HT, Chen CH, Zhang KL, Chang CH, Lin PC, Huang CYF

BACKGROUND: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have...
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