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Chemoresistance in ovarian cancer: exploiting cancer stem cell metabolism

Li SS, Ma J, Wong AS

Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent recurrence in patients with advanced diseases remains...
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Diabetes Promotes Myocardial Fibrosis via AMPK/EZH2/PPAR-γ Signaling Pathway

Li SS, Pan L, Zhang ZY, Zhou MD, Chen XF, Qian LL, Dai M, Lu J, Yu ZM, Dang S, Wang RX

Background: Diabetes-induced cardiac fibrosis is one of the main mechanisms of diabetic cardiomyopathy. As a common histone methyltransferase, enhancer of zeste homolog 2 (EZH2) has been implicated in fibrosis progression...
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