- Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
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So I, Ashmole I, Soh H, Park C, Spencer P, Leyland M, Stanfield
- KMID: 2071587
- Korean J Physiol Pharmacol.
- 2003 Jun;7(3):131-142.
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or... -
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- Multiple Residues in the P-Region and M2 of Murine Kir 2.1 Regulate Blockage by External Ba2+
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Lee YM, Thompson G, Ashmole I, Leyland M, So I, Stanfield
- KMID: 2285373
- Korean J Physiol Pharmacol.
- 2009 Feb;13(1):61-70.
- doi: 10.4196/kjpp.2009.13.1.61
We have examined the effects of certain mutations of the selectivity filter and of the membrane helix M2 on Ba2+ blockage of the inward rectifier potassium channel, Kir 2.1. We... -
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