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Novel Agents in the Treatment of Chronic Lymphocytic Leukemia

Choi CW

Chronic lymphocytic leukemia (CLL) is an indolent B-cell leukemia, and the most common leukemia in the Western world. While CLL is currently a rare leukemia type in Korea, the prevalence...
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A case report of near-triploid in adult acute lymphocytic leukemia

Jun CK, Cha JY, Oh HM, Shin YS, Kim YK, Kim SY, Kim YJ, Park BY, Cho MK, Lee GJ, Lee KI, Lee EH

  • KMID: 1601339
  • Korean J Med.
  • 2001 Aug;61(2):190-194.
In addition to age, white cell count and immunophenotype, karyotype has been reported to be one of the important prognostic factors in acute lymphocytic leukemias.Furthermore 70 percent of patients with...
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A Case Report of Mantle Cell Lymphoma in Leukemic Phase

Hwang MW, Choi HK, Yoon SY, Kim AR, Lee KN

  • KMID: 2089440
  • Korean J Clin Pathol.
  • 1997 Aug;17(4):539-546.
Recently, we experienced a patient with a B cell leukemia which could not be classified as chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PL) or follicular lymphoma in leukemic phase. He...
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Fludarabine and Rituximab in Relapsed or Refractory Hairy Cell Leukmia Variant: A Case Report and Review of Literature

Lee JW, Choi YM, Yang JY, Han SM, Kim BS, Nam SH

Hairy cell leukemia (HCL) is a rare chronic B cell leukemia morphologically characterized by cells with an abundant cytoplasm and hair-like projections that can be found in the peripheral blood...
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Chronic Lymphocytic Leukemia-Era of Targeted Therapy

Shin DY, Kim I

  • KMID: 2267805
  • Korean J Med.
  • 2013 Aug;85(2):141-153.
Chronic lymphocytic leukemia (CLL) is a unique indolent B-cell leukemia which is rare in Korea. Many patients with early stage CLL do not require immediate treatment, while those with advanced...
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Silencing the PIK3CA Gene Enhances the Sensitivity of Childhood Leukemia Cells to Chemotherapy Drugs by Suppressing the Phosphorylation of Akt

Liang X, Xin X, Qi D, Fu C, Ding M

PURPOSE: This study aimed to investigate the effects of PIK3CA on the sensitivity of acute B lymphocytic leukemia cells (Nalm-6 cells) to chemotherapy drugs. MATERIALS AND METHODS: Children's normal B lymphocytes...
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JL1 Antigen Expression on Bone Marrow Lymphoma Cells from Patients With Non-Hodgkin Lymphoma

Kim MS, Park CJ, Cho YU, Jang S, Seo EJ, Park CS, Huh J, Im HJ, Seo JJ, Yoon DH, Suh C

BACKGROUND: JL1, a CD43 epitope and mucin family cell surface glycoprotein, is expressed on leukemic cells. An anti-JL1 antibody combined with a toxic substance can have targeted therapeutic effects against...
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Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers

Park SR

Activation-induced cytidine deaminase (AID) is an enzyme that is predominantly expressed in germinal center B cells and plays a pivotal role in immunoglobulin class switch recombination and somatic hypermutation for...
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