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The Prevalence of Founder Mutations among Individuals from Families with Familial Pancreatic Cancer Syndrome

Lener MR, Kashyap A, Kluźniak , Cybulski C, Soluch A, Pietrzak S, Huzarski T, Gronwald J, Lubiński

PURPOSE: Familial pancreatic cancer describes families with at least two first-degree relatives with pancreatic cancer that do not fulfil the criteria of other inherited tumor syndromes with increased risks of...
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Serum Concentrations of Selenium and Copper in Patients Diagnosed with Pancreatic Cancer

Lener MR, Scott RJ, Wiechowska-Kozłowska A, Serrano-Fernández P, Baszuk P, Jaworska-Bieniek K, Sukiennicki G, Marciniak , Muszyńska M, Kładny J, Gromowski , Kaczmarek , Jakubowska A, Lubiński

PURPOSE: Understanding of the etiology and pathogenesis of pancreatic cancer (PaCa) is still insufficient. This study evaluated the associations between concentrations of selenium (Se) and copper (Cu) in the serum...
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Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland

Dębniak T, Scott RJ, Lea RA, Górski B, Masojć B, Cybulski C, Kram A, Maleszka R, Gromowski , Paszkowska-Szczur K, Kashyap A, Lener MR, Malińska , Rogoża E, Murawa D, Rudnicka H, Deptuła J, Lubiński

PURPOSE: Germline mutations within melanoma susceptibility genes are present only in minority of melanoma patients and it is expected that additional genes will be discovered with next generation sequence technology...
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