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Molecular Epidemiology of Legionella pneumophila Isolated from Bath Facilities of Public Establishments in Seoul

Jeon SJ, Jung JH, Jin YH, Lee JK, Oh YH, Choi SM

The genus Legionella is common in aquatic environments. Some species of Legionella are recognized as potential opportunistic pathogens for human, notably Legionella pneumophila that causes Legionellosis. During the summer season...
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Production and Characterization of Genus-, Species-Specific Monoclonal Antibodies of Legionella

Lee HK, Park MS, Park MY, Min KH

  • KMID: 1615423
  • J Bacteriol Virol.
  • 2003 Mar;33(1):39-50.
To use in the identification of Legionella pneumophila isolates, one Legionella genus-specific, an two L. pneumophila species-specific monoclonal antibodies (MAbs) were produced. Reactivities of the MAbs with Legionella species and...
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Molecular Strain Typing of Legionella Isolates from Water in Cooling Towers of Big Buildings in Busan, Korea

Kim JM, Jeong SH, Seo D, Park EH, Song EJ, Choi JC, Lee EY, Chang CL

  • KMID: 2089697
  • Korean J Clin Microbiol.
  • 2004 Mar;7(1):38-42.
BACKGROUND: It is important to define a source of infection when outbreak of Legionella infections has occurred. The performance of a molecular strain typing method was evaluated for environmental and...
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Molecular Epidemiologic Analysis of Legionella pneumophila by Infrequent-Restriction-Site Polymerase Chain Reaction

Kim JM, Kim KH, Song EJ, Lee SM, Lee EY, Park EH, Chang CL

  • KMID: 2146987
  • Korean J Clin Microbiol.
  • 2006 Apr;9(1):24-29.
BACKGROUND: The frequent outbreak of legionellosis makes it critical to identify infection sources for the prevention and blockade of transmission of the disease. METHODS: Thirty-one strains of Legionella pneumophila isolated from...
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The Etiological Role of Legionella Pneumophila in Patients with Community-Acquired Pneumonia in Korea

Song HS, Suh JH, Ahn JH, Yoon BI, Lee SJ, Lee MG, Jun MJ, Kang MJ, Lee JM, Kim DG, Son JW, Park MJ, Hyun IG, Jung KS

BACKGROUND: Legionella pneumophila has been recognized as an important cause of community-acquired pneumonia(CAP) requiring hospitalization. However, epidemiological data on the occurrence of legionella-related pneumonia is unavailable in Korea. The purpose...
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A Molecular Epidemiological Study on a Cluster of Legionella Pneumonia Occurred in a Tertiary-Care Hospital

Sohn JW, Cheong HJ, Woo HJ, Kim WJ, Kim MJ, You SH, Park SC, Lee DH, Lee CK, Han SI, Jin HC

  • KMID: 2248569
  • Korean J Infect Dis.
  • 1998 Jun;30(3):218-226.
BACKGROUND: Because of the ubiquity of Legionella species in aquatic environments, molecular epidemiological analysis of Legionella isolates is important in investigation for source of infection and subsequent control of nosocomial...
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Determination of Proper Condition for Detection of Legionella pneumophila by Polymerase Chain Reaction

Jung DW, Lee HC, Chay KO, Chung JK, Ha DR, Ryu PY

  • KMID: 1807455
  • Chonnam Med J.
  • 2000 Jun;36(2):139-147.
BACKGROUND: Legionella pneumophila is the causative agent of Legionnaires' disease, a severe pneumonia, and the nonpneumonic syndrome Pontiac fever. Isolation of L. pneumophila from the patient specimens and environment is...
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A Surveillance Study of Cooling Tower Water of Large Buildings in Seoul City for Legionella Species with Molecular Analysis

Kim KB, Kim WJ, Kim MJ, Park SC, You SH, Shim HS, Ham HJ, Park SG

  • KMID: 2248568
  • Korean J Infect Dis.
  • 1998 Jun;30(3):207-217.
BACKGROUND: To prevent and control legionellosis outbreaks, it is important to monitor cooling towers for Legionella and establish epidemiological markers. We determined level of contamination with Legionella of cooling tower...
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Comparative Study of Pneumonia Caused by Streptococcus pneumonia and Legionella pneumophila

Lyu J, Song JW, Choi CM, Oh YM, Lee SD, Kim WS, Kim DS, Kim MN, Shim TS

BACKGROUND: Legionella pneumophila has been recognized as an important cause of pneumonia. However, limited data are available in the literature regarding legionella pneumonia in Korea. The objective of this study...
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Molecular Genetic Typing of Legionella pneumophila Strains Isolated in Jejudo, Korea

Kim BJ, Park CG, Kim HY, Han CS, Kim SY, Kim SY, Lee J, Hong SC, Lee KH

Twenty two strains of Legionella species isolated from Jejudo, Korea were identified by comparing the rpoB (300 bp), dotA (360 bp), and mip (396 bp) gene sequence analysis. Furthermore, their...
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Evaluation of EuDxâ„¢-PN MLC Detection Kit for Detection of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila in Respiratory Specimens

Lee MK, Sung H, Cho AR, Chi HY

BACKGROUND: Infection by the intracellular bacteria Mycoplasma pneumoniae, Chamydophila pneumoniae, and Legionella pneumophila are common causes of community-acquired pneumonia (CAP). This study describes the evaluation of a new multiplex real-time...
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A Case of Fatal Nosocomial Legionnaires' Disease by Legionella pneumophila Serogroup 1

Kim KB, Kang MS, Chung HJ, Woo HJ, Kim MJ, You SH, Park SC

  • KMID: 1557278
  • Korean J Infect Dis.
  • 1998 Feb;30(1):106-110.
Nosocomial Legionnaires' disease has often been documented to occur in immunocompromised patients and to be severe, potentially fatal, pneumonia. We report a case of fatal nosocomial Legionnaires' disease developed shortly...
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Discovery of Diagnostic Biomarkers for Legionnaires' Disease: Virulence Gene Expression Profiling of Legionella pneumophila serogroup 1 in A/J Mouse Model

Kim SM, Sim HS, Kim HS, Shim HK, Yoon YK, Kim JY, Park YS, Park DW, Sohn JW, Kim MJ

BACKGROUND: Legionella pneumophila is the causative agent of Legionnaires' disease, a severe form of pneumonia. After L. pneumophila is inhaled through contaminated aerosols, it is phagocytized by alveolar macrophages, multiplies...
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A Case of Community-acquired Legionnaires' Disease in a Renal Transplant Recipient

Seog W, Jung YJ, Park HW, Lee HK, Park MS, Park MY, Park KS, Oh MD, Ahn C, Kim EC, Choe KW

  • KMID: 2147946
  • Korean J Infect Dis.
  • 1999 Aug;31(4):353-357.
Legionella species are causative agents of both community-acquired and nosocomial pneumonia. The spectrum of disease ranges from asymptomatic infection to serious disease and two specific syndromes are identified, i.e., Legionnaires'...
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Community-acquired Legionnaires’ Disease in a Newly Constructed Apartment Building

Ryu S, Yang K, Chun BC

OBJECTIVES: Legionnaires' disease (LD) is a severe type of pneumonia caused by inhalation of aerosols contaminated with Legionella. On September 22, 2016, a single case of LD was reported from...
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Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages

Shim HK, Kim JY, Kim MJ, Sim HS, Park DW, Sohn JW, Kim MJ

Legionella bacterium, an intracellular pathogen of mononuclear phagocytes, causes acute fatal pneumonia, especially in patients with impaired cellular immune responses. Until recently, however, the toll-like receptor (TLR) engagement of bacterial...
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Molecular Characterization of Legionellosis Drug Target Candidate Enzyme Phosphoglucosamine Mutase from Legionella pneumophila (strain Paris): An In Silico Approach

Hasan A, Mazumder H, Khan A, Hossain MU, Chowdhury

The harshness of legionellosis differs from mild Pontiac fever to potentially fatal Legionnaire's disease. The increasing development of drug resistance against legionellosis has led to explore new novel drug targets....
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Comparison of Sputum and Nasopharyngeal Swab Specimens for Molecular Diagnosis of Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila

Cho MC, Kim H, An D, Lee M, Noh SA, Kim MN, Chong YP, Woo JH

BACKGROUND: Differentiation of atypical pathogens is important for community-acquired pneumonia (CAP). In this study, we compared sputum and nasopharyngeal swabs (NPS) for use in detection of Mycoplasma pneumoniae (MP), Chlamydophila...
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Mycoplasma pneumoniae Pneumonia Unresponsive to Macrolide Treatment

Ji M, Sung H, Shim TS, Jang W, Kim MN

  • KMID: 2312211
  • Lab Med Online.
  • 2012 Oct;2(4):226-231.
We present a case of community-acquired pneumonia (CAP) that developed in a previously healthy young woman. She was diagnosed with Mycoplasma pneumoniae pneumonia, but did not respond to macrolide treatment....
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Clinical Evaluation of the Multiplex PCR Assay for the Detection of Bacterial Pathogens in Respiratory Specimens from Patients with Pneumonia

Jung CL, Lee MA, Chung WS

BACKGROUND: Community-acquired pneumonia (CAP) is a major infectious disease with significant morbidity and mortality worldwide. Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis are common...
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