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Animal models of hemorrhage, parameters, and development of hemostatic methods

Darya G, Mohammadi H, Dehghan Z, Nakhaei A, Derakhshanfar A

Hemorrhage is a prevalent side effect of various injuries and can be life-threatening in certain instances. It is categorized into compressible and non-compressible types, each necessitating distinct modeling, laboratory assessments,...
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An animal model of severe acute respiratory distress syndrome for translational research

Chu K, Lai C, Chen Y, Kuo F, Chen I, Jiang Y, Liu Y, Ko T, Fu Y

Background Despite the fact that an increasing number of studies have focused on developing therapies for acute lung injury, managing acute respiratory distress syndrome (ARDS) remains a challenge in intensive care medicine. Whether the pathology of animal models with acute lung injury...
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Measuring energy expenditure in Göttingen Minipigs using indirect calorimetry: validation and methodological considerations

Bredum S, Jacobsen J, Cirera S, Christoffersen B

Background Obesity affects nearly a billion people globally and is associated with various health consequences. Current anti-obesity medications primarily target appetite, but drug candidates that modulate energy expenditure (EE) and substrate utilization based on respiratory exchange ratio (RER) are...
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Drug screening for ischemic stroke using larvae and adult zebrafish model: a review

Nayaka N, Adnyana I, Anggadiredja K, Wibowo I

Ischemic stroke (IS) is the most recorded case of stroke that is caused by decreased blood flow to the brain. Nowadays, therapeutical agents for IS are limited and they have not shown maximum clinical results. Therefore, the exploration of new candidates for IS treatment continues to be...
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Carvacrol attenuated haloperidol-induced Parkinson’s disease via TNF/NFκβ-NLRP3-mediated pyroptosis

Albaqami F, Ahmad KW, Shah FA

Background Parkinson’s disease is a debilitating and the second most common neurodegenerative disorder with a high prevalence. Parkinson’s disease has a multifaceted etiology characterized by an altered redox state and...
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Zebrafish as a model for human epithelial pathology

Abu-Siniyeh A, Khataibeh M, Al-Zyoud W, Holi M

Zebrafish (Danio rerio) have emerged as an influential model for studying human epithelial pathology, particularly because of their genetic similarity to humans and their unique physiological traits. This review explores...
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Correction: Swallowing‑related muscle inflammation and fibrosis induced by a single dose of radiation exposure in mice

Soejima S, Wu C, Matsuse H, Terakado M, Okano S, Inoue T, Kumai Y

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Effects of Cirsium japonicum var. maackii on avelliation of metabolic disease by improving insulin resistance

Yoon HB, Jang Y, Paik HG, Choi H, Choi J, Kwon J

Background Metabolic syndrome (MetS) refers to a group of risk factors that cause health problems, such as obesity, diabetes, dyslipidemia, and hyperglycemia. MetS is characterized by insulin resistance, which leads...
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Regulatory roles of eugenol in paraquataltered SNCA/LZTS3/MAPT in the cerebellum of Wistar rats

Uchewa OO, Ibegbu AO, Okafor SO, Nwafor JA, Egwu OA

Background The Microtubules-associated protein tau (MAPT), alpha-synuclein (SNCA), and leucine zipper tumor suppressor 3 (LZTS3) genes are implicated in neurodegeneration and tumor suppression, respectively. This study investigated the regulatory roles...
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