- A review of animal models utilized in preclinical studies of approved gene therapy products: trends and insights
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Soufizadeh P, Mansouri V, Ahmadbeigi N
- KMID: 2557882
- Lab Anim Res.
- 2024 Jun;40(2):121-138.
- doi: 10.1186/s42826-024-00195-6
Scientific progress heavily relies on rigorous research, adherence to scientific standards, and transparent reporting. Animal models play a crucial role in advancing biomedical research, especially in the field of gene therapy. Animal models are vital tools in preclinical research, allowing... -
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- Non-classical animal models for studying adrenal diseases: advantages, limitations, and implications for research
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Bilyalova A, Bilyalov A, Filatov N, Shagimardanova E, Kiyasov A, Vorontsova M, Gusev O
- KMID: 2557883
- Lab Anim Res.
- 2024 Jun;40(2):139-149.
- doi: 10.1186/s42826-024-00212-8
The study of adrenal disorders is a key component of scientific research, driven by the complex innervation, unique structure, and essential functions of the adrenal glands. This review explores the... -
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- Artificial intelligence generated clinical score sheets: looking at the two faces of Janus
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Berce C
- KMID: 2557896
- Lab Anim Res.
- 2024 Jun;40(2):287-291.
- doi: 10.1186/s42826-024-00206-6
In vivo experiments are increasingly using clinical score sheets to ensure minimal distress to the animals. A score sheet is a document that includes a list of specific symptoms, behaviours... -
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- Refined protocol for newly onset identification in non-obese diabetic mice: an animal-friendly, cost-effective, and efficient alternative
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Liao CC, Hsieh CC, Shia WC, Chou MY, Huang CC, Lin JH, Lee SH, Sung HH
- KMID: 2557894
- Lab Anim Res.
- 2024 Jun;40(2):269-279.
- doi: 10.1186/s42826-024-00202-w
Background Therapeutic interventions for diabetes are most effective when administered in the newly onset phase, yet determining the exact onset moment can be elusive in practice. Spontaneous autoimmune diabetes among... -
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- Swallowing‑related muscle inflammation and fibrosis induced by a single dose of radiation exposure in mice
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Soejima S, Wu C, Matsuse H, Terakado M, Okano S, Inoue T, Kumai Y
- KMID: 2557884
- Lab Anim Res.
- 2024 Jun;40(2):150-158.
- doi: 10.1186/s42826-024-00199-2
Background Although radiotherapy is commonly used to treat head and neck cancer, it may lead to radiation-asso‑ ciated dysphagia (RAD). There are various causes of RAD, however, the mechanism has not yet been fully identified. Currently, the only effective treatment for RAD... -
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- The preventive effect of Gastrodia elata Blume extract on vancomycin‑induced acute kidney injury in rats
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Lee Y, Park Y, Lee H, Park H, Lee H, Kim G, Kim S, Shin J
- KMID: 2557886
- Lab Anim Res.
- 2024 Jun;40(2):169-180.
- doi: 10.1186/s42826-024-00200-y
Background Gastrodia elata Blume (GEB), a traditional medicinal herb, has been reported to have pharmacological effect including protection against liver, neuron and kidney toxicity. However, explanation of its underlying mecha‑ nisms remains a great challenge. This study investigated... -
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- Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis
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Soto N, Cervantes J, Aceñero M, Beauregard MC
- KMID: 2557893
- Lab Anim Res.
- 2024 Jun;40(2):258-268.
- doi: 10.1186/s42826-024-00211-9
Background Necrotizing enterocolitis (NEC) is a severe inflammatory bowel disease in neonates. Our group has developed an experimental model of NEC, with an effectiveness of 73%. Cannabidiol (CBD) is an innovative treatment for neonatal cerebral hypoxic-ischemic pathologies due to its neuroprotective effect, as a potent... -
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- Predicting altered bone biomechanics in juvenile mice: insights from microgravity simulation, loading interventions, and Raman Spectroscopy
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Berteau J
- KMID: 2557889
- Lab Anim Res.
- 2024 Jun;40(2):213-222.
- doi: 10.1186/s42826-024-00207-5
Background Microgravity, a condition experienced in a spatial environment, poses unique challenges to the skeletal system, particularly in juvenile organisms. This study aimed to investigate alterations in bone biomechanics of juvenile mice due to unloading – that simulates microgravity in the laboratory—and the effects... -
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- Intraperitoneal versus intranasal administration of lipopolysaccharide in causing sepsis severity in a murine model: a preliminary comparison
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Jiao Y, Tong C, Zhao L, Zhang Y, Nicholls J, Rainer T
- KMID: 2557895
- Lab Anim Res.
- 2024 Jun;40(2):280-286.
- doi: 10.1186/s42826-024-00205-7
Community-acquired respiratory infection is the commonest cause of sepsis presenting to emergency departments. Yet current experimental animal models simulate peritoneal sepsis with intraperitoneal (I.P.) injection of lipopolysaccharide (LPS) as the predominant route. We aimed to compare the progression of organ injury between I.P.... -
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- Quantification of 11 metabolites in rat urine after exposure to organophosphates
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Leninsky M, Sobolev V, Sokolova M, Voitenko N, Skvortsov N
- KMID: 2557891
- Lab Anim Res.
- 2024 Jun;40(2):233-248.
- doi: 10.1186/s42826-024-00209-3
Background The aim of the study was to develop a technique for quantitative determination of rat urine metabolites by HPLC–MS/MS, which can be used to search for biomarkers of acute intoxication with organophosphates (OPs). Results The content of metabolites in the urine of rats exposed to a single dose... -
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- Immune profiling of mouse lung adenocarcinoma paraffin tissues using multiplex immunofluorescence panel: a pilot study
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Zhai J, Tamegnon A, Jiang M, Pandurengan RK, Parra ER
- KMID: 2557892
- Lab Anim Res.
- 2024 Jun;40(2):249-257.
- doi: 10.1186/s42826-024-00210-w
Background Immune profiling has become an important tool for identifying predictive, prognostic and response biomarkers for immune checkpoint inhibitors from tumor microenvironment (TME). We aimed to build a multiplex immunofluorescence... -
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- Biochemical, morphological and molecular assessments of n butanol fraction of Phoenix dactylifera L. following exposure to inorganic mercury on the liver of Wistar rats
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Abubakar MG, Agbon A, Musa S, Hamman W, Oladele S
- KMID: 2557887
- Lab Anim Res.
- 2024 Jun;40(2):181-196.
- doi: 10.1186/s42826-024-00203-9
Background Mercury chloride (HgCl2 ) damages tissues it comes in contact with in sufficient concentration. This study evaluated the protective effects of n-butanol fraction of -
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- Evaluation of Artemisia dubia folium extract‑mediated immune efficacy through developing a murine model for acute and chronic stages of atopic dermatitis
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Acharya M, Gautam R, Yang S, Jo J, Maharjan A, Lee D, Ghimire N, Min B, Kim C, Kim H, Heo Y
- KMID: 2557885
- Lab Anim Res.
- 2024 Jun;40(2):159-168.
- doi: 10.1186/s42826-024-00201-x
Background Atopic dermatitis (AD) is a biphasic type of skin inflammation characterized by a predominance of type-2 (TH2) and type-1 (TH1) helper T cell-biased immune responses at the acute and persistent chronic phases, respectively. The present study was aimed to evaluate the efficacy... -
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- Endosulfan induces reproductive & genotoxic effect in male and female Swiss albino mice
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P, Kumar A, Ali M, Srivastava A, Kumar R, Ghosh AK
- KMID: 2557890
- Lab Anim Res.
- 2024 Jun;40(2):223-232.
- doi: 10.1186/s42826-024-00208-4
Background Toxicity by pesticide has become a global health issue and leaves a harmful impact on human health via various ways. The people exposed to pesticides in the rural population... -
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- Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway
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Osama HM, Khadrawy SM, EL-Nahass ES, Othman SI, Mohamed HM
- KMID: 2557888
- Lab Anim Res.
- 2024 Jun;40(2):197-212.
- doi: 10.1186/s42826-024-00204-8
Background Thyroid hormones (THs) regulate growth, development and function of different tissues. Hypothyroidism is a common clinical disorder characterized by deficiency in THs and adversely affects the development and functions... -
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