- Regular medical checkup program (in K‑MEDI hub) to enhance the welfare of laboratory dogs and pigs
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Lee G, Jo W, Park J, Kang T, Sung S, Oh T, Kim K
- KMID: 2554152
- Lab Anim Res.
- 2023 Dec;39(4):298-307.
- doi: 10.1186/s42826-023-00170-7
Background The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institutes. This study aims to describe the process and findings of veterinary medical... -
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- Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans
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Lue P, Oliver M, Neeff M, Thorne P, Suzuki‑Kerr H
- KMID: 2554149
- Lab Anim Res.
- 2023 Dec;39(4):250-268.
- doi: 10.1186/s42826-023-00182-3
Sensorineural hearing loss (SNHL), caused by pathology in the cochlea, is the most common type of hearing loss in humans. It is generally irreversible with very few effective pharmacological treatments available to prevent the degenerative changes or minimise the impact. Part of this has been... -
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- Insight into the emerging and common experimental in‑vivo models of Alzheimer’s disease
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Dhapola R, Kumari S, Sharma P, HariKrishnaReddy D
- KMID: 2554150
- Lab Anim Res.
- 2023 Dec;39(4):269-286.
- doi: 10.1186/s42826-023-00184-1
Alzheimer’s disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder. As the exact cause of the disease is still unclear, the drug development is very challenging. This review encompasses the commonly used AD models involving various chemicals, heavy metals... -
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- Feline mammary carcinoma‑derived extracellular vesicle promotes liver metastasis via sphingosine kinase‑1‑mediated premetastatic niche formation
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Chang Y, Liu H, Chuang H, Liao J, Kao P, Chan H, Chen T, Wang Y
- KMID: 2554155
- Lab Anim Res.
- 2023 Dec;39(4):329-343.
- doi: 10.1186/s42826-023-00180-5
Background Feline mammary carcinoma (FMC) is one of the most prevalent malignancies of female cats. FMC is highly metastatic and thus leads to poor disease outcomes. Among all metastases, liver metastasis occurs in about 25% of FMC patients. However, the mechanism... -
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- Comparison of digital and traditional skin wound closure assessment methods in mice
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Huang C, Siwan E, Fox S, Longfield M, Twigg S, Min D
- KMID: 2554153
- Lab Anim Res.
- 2023 Dec;39(4):308-316.
- doi: 10.1186/s42826-023-00176-1
Background Chronic skin wounds are a common complication of many diseases such as diabetes. Various traditional methods for assessing skin wound closure are used in animal studies, including wound tracing, calliper measurements and histological analysis. However, these... -
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- Compositional changes in fecal microbiota in a new Parkinson’s disease model: C57BL/6‑Tg(NSE‑haSyn) mice
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Kim J, Kwon K, Jin Y, Seol A, Song H, Roh Y, Kim T, Park E, Park G, Park J, Jung Y, Cho J, Hwang D
- KMID: 2554158
- Lab Anim Res.
- 2023 Dec;39(4):371-384.
- doi: 10.1186/s42826-023-00181-4
Background The gut–brain axis (GBA) in Parkinson’s disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut microbiota being considered one of the major treatment targets for neurodegenerative disease. Therefore, this study examined the compositional changes... -
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- Variation of sexual dimorphism and asymmetry in disease expression of inflammatory arthritis among laboratory mouse models with different genomic backgrounds
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Dong W, Tian C, Li Z, Brand D, Cao Y, Liu X, Ma J, Chai A, Myers L, Yan J, Hasty K, Stuart J, Jiao Y, Gu W, Cai X
- KMID: 2554161
- Lab Anim Res.
- 2023 Dec;39(4):402-410.
- doi: 10.1186/s42826-023-00185-0
Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse models with different genomic backgrounds. Disease data of sex and limbs accumulated in the past more than two decades from four unique... -
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- Establishment of an image evaluation grading criteria for experimental stifle joint osteoarthritis in dogs: an X‑ray and CT imaging study
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Rhee B, Jin C, Shin S, Choi H, Lee Y, Kim S
- KMID: 2554160
- Lab Anim Res.
- 2023 Dec;39(4):395-401.
- doi: 10.1186/s42826-023-00186-z
Background This study aimed to establish an image evaluation grading criteria for experimental stifle joint osteoar‑ thritis (OA) in anterior cruciate ligament transection induced OA beagle dog models. The severity of OA was assessed using X-ray... -
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- Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N‑Trp53tm1Hw1 with TALEN‑mediated Trp53 mutant gene
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Yun W, Kim J, Jin Y, Roh Y, Song H, Seol A, Kim T, Min K, Park E, Park G, Kang H, Choi Y, Hwang D
- KMID: 2554151
- Lab Anim Res.
- 2023 Dec;39(4):287-297.
- doi: 10.1186/s42826-023-00175-2
Background To evaluate the chemosensitivity to doxorubicin (DOX) in two primary cells derived from a tumor of FVB/N-Trp53tm1Hw1 knockout (KO) mice with TALEN-mediated Trp53 mutant gene, we evaluated the cell survivability, cell cycle distribution, apoptotic cell numbers and apoptotic... -
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- Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea
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Koriem K, Abdeen A
- KMID: 2554156
- Lab Anim Res.
- 2023 Dec;39(4):344-355.
- doi: 10.1186/s42826-023-00179-y
Background Diarrhea is the increase of excretion of human water content and an imbalance in the physiologic processes of the small and large intestine while shikimic acid is an important biochemical metabolite in plants. This study aims to study the anti-diarrheal activity of shikimic acid through restoring kidney function,... -
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- IL‑4/IL‑4 Ab complex enhances the accumulation of both antigen‑specific and bystander CD8 T cells in mouse lungs infected with influenza A virus
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Park H, Choi E, Choi S, Choi Y, Lee J, Jung K
- KMID: 2554159
- Lab Anim Res.
- 2023 Dec;39(4):385-394.
- doi: 10.1186/s42826-023-00183-2
Background Unlike conventional T cells, innate and virtual-memory CD8 T cells in naïve mice acquire their memory phenotypes and functions in the absence of antigenic encounters in a cytokine-dependent manner. The relevant cytokines include interleukin-4 (IL-4), type I... -
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- Promising improvement in infected Wound Healing in Type two Diabetic rats by Combined effects of conditioned medium of human adipose‑derived stem cells plus Photobiomodulation
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Sohrabi K, Ahmadi H, Amini A, Ahrabi B, Mostafavinia A, Omidi H, Mirzaei M, Fathabady F, Fridoni M, Rahmannia M, Chien S, Bayat M
- KMID: 2554157
- Lab Anim Res.
- 2023 Dec;39(4):356-370.
- doi: 10.1186/s42826-023-00178-z
Background We aimed to examine the accompanying and solo impacts of conditioned medium of human adiposederived stem cells (h-ASC-COM) and photobiomodulation (PBM) on the maturation stage of an ischemic infected delayed-healing wound model (IIDHWM) of rats with type 2 diabetes (TIIDM). Results Outcomes... -
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- Prevention of severe lung immunopathology associated with influenza infection through adeno‑associated virus vector administration
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Choi E, Park H, Choi S, Lee J, Jung K
- KMID: 2554154
- Lab Anim Res.
- 2023 Dec;39(4):317-328.
- doi: 10.1186/s42826-023-00177-0
Background Influenza A viruses (IAVs) have long posed a threat to humans, occasionally causing significant morbidity and mortality. The initial immune response is triggered by infected epithelial cells, alveolar macrophages and dendritic cells. However, an exaggerated innate immune... -
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