- Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
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Ahn CH, Lee WW, Jung YC, Shin JA, Hong KO, Choi S, Swarup N, Kim J, Ahn MH, Jung M, Cho SD, Jin B
- KMID: 2470017
- Lab Anim Res.
- 2019 Dec;35(4):194-201.
- doi: 10.1186/s42826-019-0028-7
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not... -
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- Involvement of immune responses in pulmonary arterial hypertension; lessons from rodent models
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Kim K, Choi JH
- KMID: 2470011
- Lab Anim Res.
- 2019 Dec;35(4):148-153.
- doi: 10.1186/s42826-019-0021-1
Pulmonary hypertension (PH) is a pathological state with sustained elevation of pulmonary artery (PA) pressure. Since the pathogenesis of PH is mostly irreversible, the disease often comes up with poor... -
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- Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines
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Kim GH, Yi SS
- KMID: 2470015
- Lab Anim Res.
- 2019 Dec;35(4):180-186.
- doi: 10.1186/s42826-019-0027-8
In the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), FMD (Foot-and-Mouth Disease) and AI (Avian Influenza) have become very... -
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- TarGo: network based target gene selection system for human disease related mouse models
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Hyung D, Mallon AM, Kyung DS, Cho SY, Seong JK
- KMID: 2470013
- Lab Anim Res.
- 2019 Dec;35(4):165-171.
- doi: 10.1186/s42826-019-0023-z
Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with detectable phenotypes are... -
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- Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep
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Kim GH, Yi SS
- KMID: 2470021
- Lab Anim Res.
- 2019 Dec;35(4):230-237.
- doi: 10.1186/s42826-019-0034-9
Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not... -
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- Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats
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Kang JB, Park DJ, Koh PO
- KMID: 2470014
- Lab Anim Res.
- 2019 Dec;35(4):172-179.
- doi: 10.1186/s42826-019-0026-9
Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral... -
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- Implication of Porphyromonas gingivalis in colitis and homeostasis of intestinal epithelium
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Seo Y, Oh SJ, Ahn JS, Shin YY, Yang JW, Kim HS
- KMID: 2470016
- Lab Anim Res.
- 2019 Dec;35(4):187-193.
- doi: 10.1186/s42826-019-0029-6
Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, has... -
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- Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad
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Kang JH, Jang YS, Lee HJ, Lee CY, Shin DY, Oh SH
- KMID: 2470020
- Lab Anim Res.
- 2019 Dec;35(4):221-229.
- doi: 10.1186/s42826-019-0030-0
Signal transducer and activator of transcription 3 (STAT3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, and immunity. For... -
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- An improvement in acute wound healing in rats by the synergistic effect of photobiomodulation and arginine
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Mostafavinia A, Bidram M, Avili AG, Mahmanzar , Karimifard SA, Sajadi E, Amini A, Hadipour Jahromy M, Ghoreishi , Chien S, Bayat M
- KMID: 2470018
- Lab Anim Res.
- 2019 Dec;35(4):202-212.
- doi: 10.1186/s42826-019-0025-x
In this probe, at first we examined the best route and dosage of arginine administration on wound healing in an excisional wound model in rats. Next, we intend to assess... -
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- Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus
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Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW
- KMID: 2470012
- Lab Anim Res.
- 2019 Dec;35(4):154-164.
- doi: 10.1186/s42826-019-0020-2
In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into... -
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- Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet
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Feyisa TO, Melka DS, Menon M, Labisso WL, Habte ML
- KMID: 2470019
- Lab Anim Res.
- 2019 Dec;35(4):213-220.
- doi: 10.1186/s42826-019-0024-y
Coffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the... -
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- Four amino acids as serum biomarkers for anti-asthma effects in the ovalbumin-induced asthma mouse model treated with extract of Asparagus cochinchinensis
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Choi JY, Kim SH, Kim JE, Park JW, Kang MJ, Choi HJ, Bae SJ, Lee JH, Jung YS, Hwang DY
- KMID: 2470022
- Lab Anim Res.
- 2019 Dec;35(4):238-247.
- doi: 10.1186/s42826-019-0033-x
The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAW) effectively prevents inflammation and remodeling of airway in the ovalbumin (OVA)-induced asthma model. To characterize biomarkers that can... -
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