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Malignant Peripheral Nerve Sheath Tumors of the Bilateral Adrenal Glands: Are They Metachronous Primary Tumors: A Case Report

Park JH, Ha SY, Cho HY

Malignant peripheral nerve sheath tumors (MPNSTs) have rarely been reported to occur in the adrenal gland and all of the reported cases were associated with neurofibromatosis, pheochromocytoma or ganglioneuroma. We...
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Cytology of Plasmacytoid Type Myoepithelioma: Report of Two Cases

Kim NR, Cho HY, Ha SY

Myoepithelioma is a rare benign tumor of salivary gland myoepithelial cells, most commonly as a spindle subtype. Here, we present two cases of fine needle aspiration cytology of plasmacytoid myoepithelioma...
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Molecular Biologic Techniques in Cytopathologic Diagnosis

Hwang TS

Molecular diagnosis is an application of the knowledge on molecular mechanisms of disease to diagnosis, therapeutic decision-making, and prognostication. Basically any molecular diagnostic technique could be used in molecular diagnostic...
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Significance of the Expression of Cathepsins B, H, & L in Colonic Epithelial Neoplasms

Sim JY, Lee MJ, Kee KH

BACKGROUND: Cathepsin is associated with tumorigenesis, tumor invasion and metastasis through its ability to induce degradation of extracellular matrix components. METHODS: To investigate the correlation between cathepsin expression and tumor progression,...
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Metastatic Osteosarcoma to the Prostate: A Case Report

Seo HY, Lee JH, Park CS, Park JG, Jung ST

The most common site for the metastasis of osteosarcoma is the lung, and other sites of metastases include the bone, lymph node, pleura and liver. Although unusual extrapulmonary metastases have...
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Malignant Mesothelioma in Body Fluids: with Special Reference to Differential Diagnosis from Metastatic Adenocarcinoma

Paik JH, Chung JH, Kim BH, Choe G

BACKGROUND: Malignant mesothelioma (MM) is a rare malignant neoplasm occurring in pleura, pericardium, and peritoneum. The differential diagnosis between MM and metastatic adenocarcinoma (MA) causes diagnostic, staging, and therapeutic dilemmas....
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Eosinophilic Fasciitis Associated with Overlying Intraepidermal Blister Formation: A Case Report

Kim NR, Chung DH, Ha SY

Eosinophilic fasciitis is a scleroderma-like disease and it may present with paraneoplastic syndrome or as an isolated form of the disease. We report here on a case of eosinophilic fasciitis...
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Enhanced Protein Expression of Signal Transducer and Activator of Transcription 3 and Protein Kinase Substrate p36 in Hepatocellular Carcinoma

Han H, Jang SH, Park CK

BACKGROUND: Signal transducers and activators of transcription 3 (STAT3) and protein kinase substrate p36 may be involved in cell proliferation, differentiation and growth. METHODS: Immunohistochemistry for STAT3 and p36 was performed...
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Squamous Cell Carcinoma of an Ileal Neobladder: A Case Report

Hong R, Choi DY, Shin DE, Moon HY, Kee KH

Bladder reconstruction using bowel segments, especially the ileum, has become a realistic option for urinary diversion. There is only one prior case of squamous cell carcinoma of the ileal neobladder...
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Clinicopathologic Characteristics of Endometrial Adenocarcinomas in Young Women

Choi G, Kim JW, Khang SK, Kim KR

BACKGROUND: Despite an increased incidence of endometrial carcinomas in young Korean women, clinicopathologic characteristics and treatment outcomes have not been analyzed. METHODS: We investigated clinicopathologic characteristics of endometrial carcinoma in 48...
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Comparison of Cytologic Evaluation between Conventional Method and CellprepPlus(R) Liquid-Based Cytology in Body Fluid

Koo JH, Lee HC, Song HG, Han HS, Lee KH, Choe KH, Lee KM, Lee OJ

BACKGROUND: Assessment of body fluid cytology is a useful means of evaluating a metastatic tumor. Liquid-based cytology (LBC) has been developed as a replacement for the conventional Papanicolaou (CP) test....
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Histologic Correlation of Atypical Glandular Cells in Cervical Smears

Chun YK, Hong SR, Kim HS, Kim JY, Kim HS

BACKGROUND: The study evaluated the histologic correlation and clinical significance of atypical glandular cells (AGC) detected either on conventional smears (CS) or liquid-based cytology (LBC). METHODS: Two hundred and seventy-seven (0.11%)...
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The EGFR Protein Expression and the Gene Copy Number Changes in Renal Cell Carcinomas

Lee S, An J, Kim A, Kim YS, Kim I, Genitourinary Pathology Study Group

BACKGROUND: The epidermal growth factor receptor (EGFR) is known to be involved in many tumor promoting activities. EGFR inhibition has been tried as a therapeutic modality in many human malignancies. METHODS:...
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Predictive Significance of KRAS and Tau for Chemoresponse in Advanced Non-Small-Cell Lung Cancer

Yoo J, Shim BY, Yoo CY, Kang SJ, Lee KY

BACKGROUND: Taxane-platinum combinations are often used as first-line treatments for patients with advanced non-small cell lung cancer (NSCLC). Response to chemotherapy for these patients is still poor. The aim of...
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The Loss of E-cadherin is Associated with the Epigenetic Alteration of CDH1 in Breast Cancer and it is also Associated with an Abnormal beta-catenin Expression in Lobular Carcinoma

Kim G, Kim JY, An HJ, Kang H, Kim TH, Shim JY, Heo JH, Park HL, Choi YK

BACKGROUND: APC and E-cadherin are the key molecules in the Wnt/beta-catenin pathway. We attempted to define the epigenetic alteration of APC and CDH1 (the E-cadherin gene) and the expression of...
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Clinicopathologic Characteristics of Left-Sided Colon Cancers with High Microsatellite Instability

Kim SK, Choi J, Kim HK, Park YN, Song SY, Kim H

BACKGROUND: High microsatellite instability (MSI-H) colorectal carcinomas (CRCs) with numerous mutations in the microsatellite sequence are characterized by a right-sided preponderance, frequent peritumoral and intratumoral lymphocytic infiltration, and frequent mucin...
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DNA Methylation Profiles of MGMT, DAPK1, hMLH1, CDH1, SHP1, and HIC1 in B-Cell Lymphomas

Kim SS, Choi YH, Han CW, Choi YD, Park Y, Lee JJ, Kim HJ, Lee IK, Lee JS, Juhng SW, Choi C

BACKGROUND: This study was designed to examine the prevalence of aberrant promoter methylation in a selected panel of genes potentially involved in lymphoid tumors. METHODS: The promoter hypermethylation status of MGMT,...
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Extramedullary B Lymphoblastic Crisis of CML, Presenting as a Leptomeningeal Tumor: A Case Report

Jeong H, Shin B, Bae SY, Lee S, Ryu Y, Kim H, Kim I

We report here on a rare case of a patient who presented with an extramedullary B lymphoblastic crisis as an initial manifestation of chronic myelogenous leukemia (CML). A 71-year-old man...
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