- IDH2 gene deficiency accelerates unilateral ureteral obstructioninduced kidney inflammation through oxidative stress and activation of macrophages
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Kim JI, Noh MR, Yoon GE, Jang HS, Kong MJ, Park KM
- KMID: 2512957
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):139-146.
- doi: 10.4196/kjpp.2021.25.2.139
Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) produces NADPH, which is known to inhibit mitochondrial oxidative stress. Ureteral obstruction induces kidney inflammation and fibrosis via oxidative stress. Here, we investigated the... -
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- Factors Influencing Intra-Operative Body Temperature in Laparoscopic Colectomy Surgery under General Anesthesia: An Observational Cohort
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Kong MJ, Yoon H
- KMID: 2391138
- J Korean Biol Nurs Sci.
- 2017 Aug;19(3):123-130.
- doi: 10.7586/jkbns.2017.19.3.123
PURPOSE: This study aimed to identify factors influencing intra-operative core body temperature (CBT), and to develop a predictive model for intra-operative CBT in laparoscopic abdominal surgery. METHODS: The prospective observational study... -
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- Rac1 inhibition protects the kidney against kidney ischemia/ reperfusion through the inhibition of macrophage migration
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Park YR, Kong MJ, Noh MR, Park KM
- KMID: 2541637
- Korean J Physiol Pharmacol.
- 2023 May;27(3):257-265.
- doi: 10.4196/kjpp.2023.27.3.257
Kidney ischemia/reperfusion (I/R) injury, a common cause of acute kidney injury (AKI), is associated with the migration of inflammatory cells into the kidney. Ras-related C3 botulinum toxin substrate 1 (Rac1),... -
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- High water intake induces primary cilium elongation in renal tubular cells
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Kong MJ, Han SJ, Seu SY, Han KH, Lipschutz JH, Park KM
- KMID: 2557314
- Kidney Res Clin Pract.
- 2024 May;43(3):313-325.
- doi: 10.23876/j.krcp.23.087
Background: The primary cilium protrudes from the cell surface and functions as a mechanosensor. Recently, we found that water intake restriction shortens the primary cilia of renal tubular cells, and... -
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- Shortening of primary cilia length is associated with urine concentration in the kidneys
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Kong MJ, Han SJ, Seu SY, Han KH, Lipschutz JH, Park KM
- KMID: 2543786
- Kidney Res Clin Pract.
- 2023 May;42(3):312-324.
- doi: 10.23876/j.krcp.22.274
Background: The primary cilium, a microtubule-based cellular organelle present in certain kidney cells, functions as a mechano-sensor to monitor fluid flow in addition to various other biological functions. In kidneys,... -
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