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Histamine-Releasing Factor and Immunoglobulins in Asthma and Allergy

Kawakami T, Kashiwakura JI, Kawakami Y

Factors that can induce the release of histamine from basophils have been studied for more than 30 years. A protein termed histamine-releasing factor (HRF) was purified and molecularly cloned in...
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Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens

Kashiwakura Ji, Okayama Y, Furue M, Kabashima , Shimada S, Ra C, Siraganian RP, Kawakami Y, Kawakami T

PURPOSE: Monomeric IgE molecules, when bound to the high-affinity receptor, exhibit a vast heterogeneity in their ability to induce survival promotion and cytokine production in mast cells. At one end...
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