- The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
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Moon JS, Karunakaran U, Suma E, Chung SM, Won KC
- KMID: 2502403
- Diabetes Metab J.
- 2020 Apr;44(2):222-233.
- doi: 10.4093/dmj.2020.0053
Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential... -
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- A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense
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Karunakaran U, Park KG
- KMID: 2280711
- Diabetes Metab J.
- 2013 Apr;37(2):106-112.
- doi: 10.4093/dmj.2013.37.2.106
A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially beta-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as... -
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- O-GlcNAc Modification: Friend or Foe in Diabetic Cardiovascular Disease
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Karunakaran U, Jeoung NH
- KMID: 2029873
- Korean Diabetes J.
- 2010 Aug;34(4):211-219.
- doi: 10.4093/kdj.2010.34.4.211
O-Linked beta-N-acetyl glucosaminylation (O-GlcNAcylation) is a dynamic post-translational modification that occurs on serine and threonine residues of cytosolic and nuclear proteins in all cell types, including those involved in the... -
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- Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5
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Karunakaran U, Elumalai S, Moon JS, Jeon JH, Kim ND, Park KG, Won KC, Leem J, Lee IK
- KMID: 2442772
- Diabetes Metab J.
- 2019 Apr;43(2):192-205.
- doi: 10.4093/dmj.2018.0052
BACKGROUND: Chronic hyperglycemia has deleterious effects on pancreatic β-cell function and turnover. Recent studies support the view that cyclin-dependent kinase 5 (CDK5) plays a role in β-cell failure under hyperglycemic... -
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