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Non-Inferiority Trials in Stroke Research: What Are They, and How Should We Interpret Them?

Li L, Lioutas VA, Akyea RK, Gerner S, Lau KK, Ramage E, Katsanos AH, Howard G, Bath PM

Randomized clinical trials are important in both clinical and academic stroke communities with increasing numbers of new design concepts emerging. One of the “less traditional” designs that have gained increasing...
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Reinforcement of Transdural Angiogenesis: A Novel Approach to Treating Ischemic Stroke With Cerebral Perfusion Impairment

Hong JM, Shin HS

Cerebral hypoperfusion plays a critical role in early neurological deterioration and long-term outcomes in patients with acute ischemic stroke, which remains a major global health challenge. This review explored transdural...
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Long-Term Incidence of Gastrointestinal Bleeding Following Ischemic Stroke

Kim JY, Kim BJ, Kang J, Kim DY, Han MK, Kim SE, Lee H, Park JM, Kang K, Lee SJ, Kim JG, Cha JK, Kim DH, Park TH, Lee K, Park HK, Cho YJ, Hong KS, Choi KH, Kim JT, Kim DE, Choi JC, Oh MS, Yu KH, Lee BC, Park KY, Lee JS, Jang S, Chae JE, Lee J, Kye MS, Gorelick PB, Bae HJ, on Behalf of the CRCS-K Investigators

Background and Purpose Previous research on patients with acute ischemic stroke (AIS) has shown a 0.5% incidence of major gastrointestinal bleeding (GIB) requiring blood transfusion during hospitalization. The existing literature...
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Developing a Model of Advance Consent for Participation in Acute Stroke Trials

Seeger R, Udoh U, Dewar B, Nicholls S, Fedyk M, Gocan S, Shepherd V, Dowlatshahi D, Shamy M

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Association of Hypertension and Subclinical Organ Damage With Mortality Due to Stroke and Its Subtypes

Ariyada K, Yamagishi K, Sairenchi T, Kihara T, Iso H, Irie F

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Prevalence of Genetic Variants Causing Mendelian Stroke Among 15,548 Koreans Without Neurological Disorders

Yang JO, Lee SH, Kim HJ, Kang CH, Kim JG, Choi JC

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Direct and Indirect Effects of Prolonged Exposure to Long Working Hours on Risk Stroke Subtypes in the CONSTANCES Cohort

Fadel M, Sembajwe G, Li J, Leclerc A, Pico F, Schnitzler A, Fadel ER, Roquelaure Y, Descatha A

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Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment

Marto JP, Strambo D, Ntaios G, Nguyen TN, Wrona P, Escalard S, Marcheselli S, Mansour OY, Fuentes B, Dorobek M, Nowakowska-Kotas M, Terecoasa EO, Coutinho JM, Carvalho-Dias M, Calleja P, Sargento-Freitas J, Paiva-Nunes A, Šrámek M, Khandelwal P, Meira T, Abdalkader M, Jabbour P, Kovář M, Ayo-Martin O, Michel P, Herzig R, Członkowksa A, Demeestere J, Nogueira RG, Salerno A, Wegener S, Baumgartner P, Cereda CW, Bianco G, Beyeler M, Arnold M, Carrera E, Machi P, Altersberger V, Bonati L, Gensicke H, Bolognese M, Peters N, Wetzel S, Magriço M, Nuno Ramos J, Machado R, Maia C, Machado E, Ferreira P, Pinho-e-Melo T, Paula A, Correia MA, Castro P, Azevedo E, Albuquerque L, Nuno-Alves J, Ferreira-Pinto J, Meira T, Pereira L, Rodrigues M, Araújo A, Rodrigues M, Rocha M, Pereira-Fonseca , Ribeiro L, Varela R, Malheiro S, Cappellari M, Zivelonghi C, Sajeva G, Zini A, Mauro G, Stefano F, Migliaccio L, Sessa M, Gioia SL, Pezzini A, Sangalli D, Zedde M, Pascarella R, Ferrarese C, Beretta S, Diamanti S, Schwarz G, Frisullo G, Seners P, Sabben C, Piotin M, Maier B, Charbonnier G, Vuillier F, Legris L, Cuisenier P, Vodret FR, Marnat G, Liegey JS, Sibon I, Flottmann F, Broocks G, Gloyer NO, Bohmann FO, Schaefer JH, Nolte CH, Audebert H, Siebert E, Sykora M, Lang W, Ferrari J, Mayer-Suess L, Knoflach M, Gizewski ER, Stolp J, Stolze LJ, Nederkoorn PJ, van-den-Wijngaard I, de Meris J, Lemmen R, De Raedt S, Vandervorst F, Rutgers MP, Guilmot A, Dusart A, Bellante F, Ostos F, Gonzalez-Ortega G, Martín-Jiménez P, García-Madrona S, Cruz-Culebras A, Vera R, Matute MC, Alonso-de-Leciñana M, Rigual R, Díez-Tejedor E, Pérez-Sánchez S, Montaner J, Díaz-Otero F, Perez-de-la-Ossa N, Flores-Pina B, Muñoz-Narbona L, Chamorro A, Rodríguez-Vázquez A, Renú A, Hernandez-Fernandez F, Segura T, Tejada-Meza H, Sagarra-Mur D, Serrano-Ponz M, Hlaing T, See I, Simister R, Werring DJ, Kristoffersen ES, Nordanstig A, Jood K, Rentzos A, Šimu˚ne L, Krajíčková D, Krajina A, Mikulík R, Cviková M, Vinklárek J, Školoudík D, Roubec M, Hurtikova E, Hrubý R, Ostry S, Skoda O, Pernicka M, Kočí L, Eichlová Z, Jíra M, Panský M, Mencl P, Paloušková H, Tomek A, Janský P, Olšerová A, Havlíček R, Malý P, Trakal L, Fiksa J, Slovák M, Karlińsk M, Nowak M, Sienkiewicz-Jarosz H, Bochynska A, Homa T, Sawczynska K, Slowik A, Wlodarczyk E, Wiącek M, Tomaszewska-Lampart I, Sieczkowski B, Bartosik-Psujek H, Bilik M, Bandzarewicz A, Zielińska-Turek J, Obara K, Urbanowski P, Budrewicz S, Guziński M, Świtońska M, Rutkowska I, Sobieszak-Skura P, Łabuz-Roszak B, Dębiec A, Staszewski J, Stępień A, Zwiernik J, Wasilewski G, Tiu C, Radu RA, Negrila A, Dorobat B, Panea C, Tiu V, Petrescu S, Özcan-Özdemir A, Mahmoud M, El-Samahy H, Abdelkhalek H, Al-Hashel J, Ibrahim Ismail I, Salmeen A, Ghoreishi A, Sabetay S, Gross H, Klein P, El Naamani K, Tjoumakaris S, Abbas R, Mohamed GA, Chebl A, Min J, Hovingh M, Tsai JP, Khan MA, Nalleballe K, Onteddu S, Masoud HE, Michael M, Kaur N, Maali L, Abraham M, Bach I, Ong M, Babici D, Khawaja AM, Hakemi M, Rajamani K, Cano-Nigenda V, Arauz A, Amaya P, Llanos N, Arango A, Vences MA, Barrientos JD, Caetano R, Targa R, Scollo S, Yalung P, Nagendra S, Gaikwad A, Seo KD, on Behalf of the Global COVID-19 Stroke Registry

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Neurovascular Complications of Acute Aortic Syndrome

Zeldich D, Bierowski M, Shabo L, Yaddanapudi S, Marhefka G

Acute aortic syndromes (AAS) such as aortic dissection, intramural hematoma, and penetrating aortic ulcer pose significant neurovascular risks, affecting patient outcomes. This review examines the incidence, clinical presentation, and outcomes...
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Predictive Modeling of Symptomatic Intracranial Hemorrhage Following Endovascular Thrombectomy: Insights From the Nationwide TREAT-AIS Registry

Chen JH, Su IC, Lu YH, Hsieh YC, Chen CH, Lin CJ, Chen YW, Lin KH, Sung PS, Tang CW, Chu HJ, Fu CH, Chou CL, Wei CY, Yan SY, Chen PL, Yeh HL, Sung SF, Liu HM, Lin CH, Lee M, Tang SC, Lee IH, Chan L, Lien LM, Chiou HY, Lee JT, Jeng JS, on Behalf of the Nationwide TREAT-AIS Investigators

Background and Purpose Symptomatic intracranial hemorrhage (sICH) following endovascular thrombectomy (EVT) is a severe complication associated with adverse functional outcomes and increased mortality rates. Currently, a reliable predictive model for...
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Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial

Goyal M, Menon BK, Ospel J, Almekhlafi M, Zerna C, Nogueira R, McTaggart R, Demchuk AM, Poppe AY, Buck B, Heard K, Joshi M, Haussen D, Cutting S, Coutts SB, Roy D, Rempel JL, Field TS, Dowlatshahi D, Adel Bv, Swartz R, Shah R, Sauvageau E, Puetz V, Silver FL, Campbell B, Chapot R, Tymianski M, Hill MD, on Behalf of the ESCAPE-NA1 Investigators

Background and Purpose In the ESCAPE-NA1 (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischaemic Stroke) trial, treatment with nerinetide was associated with improved outcomes in patients who...
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Endovascular Treatment for Acute Posterior Circulation Tandem Lesions: Insights From the BASILAR and PERSIST Registries

Li W, Doheim MF, Qiu Z, Wang T, Chen Z, Zi W, Yang Q, Guan H, Qiao H, Liu W, Hu W, Liu X, Huang J, Han Z, Chen Z, Zhao Z, Sun W, Nogueira RG

Background and Purpose Limited evidence exists on the effectiveness of endovascular treatment (EVT) for acute posterior circulation tandem lesion (PCTL). This study aimed to explore the role of extracranial vertebral...
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Hemorrhagic Complications Following Endovascular Treatment for Atherothrombotic Large Vessel Occlusion

Fujiwara S, Uchida K, Ohta T, Ohara N, Kawamoto M, Yamagami H, Toyoda K, Matsumaru Y, Matsumoto Y, Todo K, Hayakawa M, Shindo S, Ota S, Morimoto M, Takeuchi M, Imamura H, Ikeda H, Tanaka K, Ishihara H, Kakita H, Sano T, Araki H, Nomura T, Beppu M, Sakakibara F, Shirakawa M, Yoshimura S, Sakai N

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Impact of Onset-to-Door Time on Endovascular Therapy for Basilar Artery Occlusion

Liu T, Tao C, Chen Z, Xu L, Zhu Y, Li R, Sun J, Wang L, Zhang C, Song J, Jing X, Qureshi AI, Abdalkader M, Nguyen TN, Nogueira RG, Saver JL, Hu W

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Parkinsonism in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: Clinical Features and Biomarkers

Chen CH, Wang TW, Cheng YW, Chu YT, Cheng MF, Chen YF, Lin CH, Tang SC

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Thrombectomy With Bridging Thrombolytic May Benefit Asian Patients More Than Non-Asian Patients: Insights From DIRECT-SAFE Sub-Analysis

Barker JL, Swarup O, Kusuma Y, Churilov L, Donnan G, Davis SM, Mitchell PJ, Yan B

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Thrombolysis in Patients With Versus Without Visible Occlusion: A Secondary Analysis From the AcT Trial

Siddiqi AZ, Ignacio K, Kaveeta C, Bala F, Ademola A, Tkach A, Buck BH, Catanese L, Hunter G, Dowlatshahi D, Shamy M, Zafar A, Field TS, Appireddy R, Wadhwa A, Sajobi T, Swartz R, Almekhlafi M, Demchuk A, Menon B, Singh N

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Differentiating Cerebral Amyloid Angiopathy From Alzheimer’s Disease Using Dual Amyloid and Tau Positron Emission Tomography

Tsai HH, Pasi M, Liu CJ, Tsai YC, Yen RF, Chen YF, Jeng JS, Tsai LK, Charidimou A, Baron JC

Background and Purpose Although amyloid positron emission tomography (PET) might provide a molecular diagnosis for cerebral amyloid angiopathy (CAA), it does not have sufficient specificity for this condition relative to...
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Narrowings of the Deep Cerebral Perforating Arteries Ostia: Geometry, Structure, and Clinical Implications

Rzeplin´ski R, Tarka S, Tomaszewski M, Kucewicz M, Acewicz A, Małachowski J, Ciszek B

Background and Purpose The pathogenesis of neurovascular diseases and various types of dementia is tightly connected to cerebral circulation. An area that requires further exploration is the system of deep...
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Medical Management of Adult Moyamoya Disease: A Review and Relevant Cases With Ischemic Events

Bang OY, Fujimura M

Moyamoya disease (MMD) is a rare and progressive cerebrovascular disorder characterized by stenosis or occlusion of the internal carotid arteries resulting in the development of fragile collateral vessels at the...
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