J Stroke.  2025 Jan;27(1):118-121. 10.5853/jos.2024.02005.

Thrombectomy With Bridging Thrombolytic May Benefit Asian Patients More Than Non-Asian Patients: Insights From DIRECT-SAFE Sub-Analysis

Affiliations
  • 1Department of Neurology, Melbourne Brain Centre, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
  • 2School of Medicine, Deakin University, Waurn Ponds, Australia
  • 3Department of Neurology National Brain Centre, Jakarta, Indonesia
  • 4Department of Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia


Reference

References

1. Yang P, Zhang Y, Zhang L, Zhang Y, Treurniet KM, Chen W, et al. Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med. 2020; 382:1981–1993.
Article
2. Zi W, Qiu Z, Li F, Sang H, Wu D, Luo W, et al. Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT randomized clinical trial. JAMA. 2021; 325:234–243.
Article
3. Mitchell PJ, Yan B, Churilov L, Dowling RJ, Bush SJ, Bivard A, et al. Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial. Lancet. 2022; 400:116–125.
Article
4. Suzuki K, Matsumaru Y, Takeuchi M, Morimoto M, Kanazawa R, Takayama Y, et al. Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial. JAMA. 2021; 325:244–253.
Article
5. Hund HM, Boodt N, Hansen D, Haffmans WA, Lycklama À Nijeholt GJ, Hofmeijer J, et al. Association between thrombus composition and stroke etiology in the MR CLEAN registry biobank. Neuroradiology. 2023; 65:933–943.
6. Fischer U, Kaesmacher J, Strbian D, Eker O, Cognard C, Plattner PS, et al. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial. Lancet. 2022; 400:104–115.
7. Di Donna A, Muto G, Giordano F, Muto M, Guarnieri G, Servillo G, et al. Diagnosis and management of tandem occlusion in acute ischemic stroke. Eur J Radiol Open. 2023; 11:100513.
Article
8. Kaesmacher J, Cavalcante F, Kappelhof M, Treurniet KM, Rinkel L, Liu J, et al. Time to treatment with intravenous thrombolysis before thrombectomy and functional outcomes in acute ischemic stroke: a meta-analysis. JAMA. 2024; 331:764–777.
9. Conroy S, Murray EJ. Let the question determine the methods: descriptive epidemiology done right. Br J Cancer. 2020; 123:1351–1352.
Article
10. Chen LH, Spagnolo-Allende A, Yang D, Qiao Y, Gutierrez J. Epidemiology, pathophysiology, and imaging of atherosclerotic intracranial disease. Stroke. 2024; 55:311–323.
Article
Full Text Links
  • JOS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2025 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr