- Cryptotanshinone Prevents the Binding of S6K1 to mTOR/Raptor Leading to the Suppression of mTORC1-S6K1 Signaling Activity and Neoplastic Cell Transformation
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Jeoung NH, Jeong JY, Kang BS
- KMID: 2517366
- J Cancer Prev.
- 2021 Jun;26(2):145-152.
- doi: 10.15430/JCP.2021.26.2.145
Cryptotanshinone is known for its inhibitory activity against tumorigenesis in various human cancer cells. However, exact mechanisms underlying the anticancer effects of cryptotanshinone are not fully elucidated. Here, we propose... -
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- Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
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Jeoung NH
- KMID: 2281531
- Diabetes Metab J.
- 2015 Jun;39(3):188-197.
- doi: 10.4093/dmj.2015.39.3.188
Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major... -
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- O-GlcNAc Modification: Friend or Foe in Diabetic Cardiovascular Disease
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Karunakaran U, Jeoung NH
- KMID: 2029873
- Korean Diabetes J.
- 2010 Aug;34(4):211-219.
- doi: 10.4093/kdj.2010.34.4.211
O-Linked beta-N-acetyl glucosaminylation (O-GlcNAcylation) is a dynamic post-translational modification that occurs on serine and threonine residues of cytosolic and nuclear proteins in all cell types, including those involved in the... -
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- Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
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Jeoung NH, Harris RA
- KMID: 2029884
- Korean Diabetes J.
- 2010 Oct;34(5):274-283.
- doi: 10.4093/kdj.2010.34.5.274
In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In... -
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- Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
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Jeong JY, Jeoung NH, Park KG, Lee IK
- KMID: 2174390
- Diabetes Metab J.
- 2012 Oct;36(5):328-335.
- doi: 10.4093/dmj.2012.36.5.328
The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it... -
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- Microarray Analysis of Papillary Thyroid Cancers in Korean
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Kim HS, Kim DH, Kim JY, Jeoung NH, Lee IK, Bong JG, Jung ED
- KMID: 964721
- Korean J Intern Med.
- 2010 Dec;25(4):399-407.
- doi: 10.3904/kjim.2010.25.4.399
BACKGROUND/AIMS: Papillary thyroid cancer (PTC) is the most common malignancy of the thyroid gland. It involves several molecular mechanisms. The BRAF V600E mutation has been identified as the most common... -
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