- Pharmacokinetic Interaction of Chrysin with Caffeine in Rats
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Noh K, Oh DG, Nepal MR, Jeong KS, Choi Y, Kang MJ, Kang W, Jeong HG, Jeong TC
- KMID: 2351695
- Biomol Ther.
- 2016 Jul;24(4):446-452.
- doi: 10.4062/biomolther.2015.197
Pharmacokinetic interaction of chrysin, a flavone present in honey, propolis and herbs, with caffeine was investigated in male Sprague-Dawley rats. Because chrysin inhibited CYP1A-selective ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase activities... -
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- Alternative Methods for Testing Botulinum Toxin: Current Status and Future Perspectives
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Nepal MR, Jeong TC
- KMID: 2503469
- Biomol Ther.
- 2020 Jul;28(4):302-310.
- doi: 10.4062/biomolther.2019.200
Botulinum toxins are neurotoxic modular proteins composed of a heavy chain and a light chain connected by a disulfide bond and are produced by Clostridium botulinum. Although lethally toxic, botulinum... -
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- Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats
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Noh K, Nepal MR, Jeong KS, Kim SA, Um YJ, Seo CS, Kang MJ, Park PH, Kang W, Jeong HG, Jeong TC
- KMID: 2380355
- Biomol Ther.
- 2015 Mar;23(2):201-206.
- doi: 10.4062/biomolther.2014.134
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the... -
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- Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition
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Bae ON, Noh M, Chun YJ, Jeong TC
- KMID: 2380357
- Biomol Ther.
- 2015 Jan;23(1):12-18.
- doi: 10.4062/biomolther.2014.102
Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in... -
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- Protective Effects of Diallyl Sulfide against Thioacetamide-Induced Toxicity: A Possible Role of Cytochrome P450 2E1
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Kim NH, Lee S, Kang MJ, Jeong HG, Kang W, Jeong TC
- KMID: 2170655
- Biomol Ther.
- 2014 Mar;22(2):149-154.
Effects of diallyl sulfide (DAS) on thioacetamide-induced hepatotoxicity and immunotoxicity were investigated. When male Sprague-Dawley rats were treated orally with 100, 200 and 400 mg/kg of DAS in corn oil... -
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- Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo
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Nepal MR, Kang MJ, Kim GH, Cha DH, Kim JH, Jeong TC
- KMID: 2513054
- Diabetes Metab J.
- 2020 Dec;44(6):908-918.
- doi: 10.4093/dmj.2019.0147
Background Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor... -
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- A Comparison of the In Vitro Inhibitory Effects of Thelephoric Acid and SKF-525A on Human Cytochrome P450 Activity
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Song M, Do H, Kwon OK, Yang EJ, Bae JS, Jeong TC, Song KS, Lee S
- KMID: 2170656
- Biomol Ther.
- 2014 Mar;22(2):155-160.
Thelephoric acid is an antioxidant produced by the hydrolysis of polyozellin, which is isolated from Polyozellus multiplex. In the present study, the inhibitory effects of polyozellin and thelephoric acid on... -
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- Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling
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Kim MJ, Kadayat T, Um YJ, Jeong TC, Lee ES, Park PH
- KMID: 2380344
- Biomol Ther.
- 2015 Mar;23(2):119-127.
- doi: 10.4062/biomolther.2014.127
Chalcones (1,3-diaryl-2-propen-1-ones), a subfamily of flavonoid, are widely known to possess potent anti-inflammatory and anti-oxidant properties. In this study, we investigated the effect of 3-(4-Hydroxyphenyl)-1-(thio3-(4-Hydroxyphenyl phen-2-yl)prop-2-en-1-one (TI-I-175), a synthetic chalcone... -
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