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Modeling the Dynamics and Control of Transmission of Schistosoma japonicum and S. mekongi in Southeast Asia

Ishikawa H, Ohmae H

A mathematical model for transmission of schistosomes is useful to predict effects of various control measures on suppression of these parasites. This review focuses on epidemiological and environmental factors in...
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Ramelteon for Delayed Sleep-wake Phase Disorder: A Case Report

Takeshima M, Shimizu T, Ishikawa H, Kanbayashi T

Recently developed melatonin receptor agonists are expected to be effective for delayed sleep-wake phase disorder (DSWPD). To date, however, no study has described the effect of melatonin receptor agonists on...
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Successful Management of Clozapine-induced Akathisia with Gabapentin Enacarbil: A Case Report

Takeshima , Ishikawa H, Kikuchi Y, Kanbayashi T, Shimizu T

The management of clozapine (CLZ)-induced adverse events affects patient prognoses. Akathisia is a relatively rare adverse event related to CLZ administration and thus the management of this syndrome is not...
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Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis

Fukui H, Chiba A, Miyazaki T, Takano H, Ishikawa H, Omori T, Mochiuzki

Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely...
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Production of cloned sei whale (Balaenoptera borealis) embryos by interspecies somatic cell nuclear transfer using enucleated pig oocytes

Lee E, Bhuiyan MM, Watanabe H, Matsuoka K, Fujise Y, Ishikawa H, Fukui Y

In this study, we examined the feasibility of using subzonal cell injection with electrofusion for interspecies somatic cell nuclear transfer (iSCNT) to produce sei whale embryos and to improve their...
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Long-term outcomes of progestin plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer patients

Mitsuhashi A, Habu Y, Kobayashi , Kawarai Y, Ishikawa H, Usui H, Shozu M

OBJECTIVE: The present study investigated long-term outcomes of medroxyprogesterone acetate (MPA) plus metformin therapy in terms of control of atypical endometrial hyperplasia (AEH) and endometrial cancer (EC), and post-treatment conception. METHODS:...
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Differentiation of Rat Dermal Mesenchymal Cells and Calcification in Three-Dimensional Cultures

Suyama T, Hatta M, Hata S, Ishikawa H, Yamazaki J

Three-dimensional (3D) cultures are known to promote cell differentiation. Previously, we investigated the differentiation of rat dermal fibroblasts to α-smooth muscle actin (α-SMA)-positive myofibroblasts through transforming growth factor (TGF)-β production...
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Differences in Perspectives of Medical Device Adverse Events: Observational Results in Training Program Using Virtual Cases

Yoon C, Nam KC, Lee YK, Kang Y, Choi SJ, Shin HM, Jang H, Kim JK, Kwon BS, Ishikawa H, Woo E

BACKGROUND: Medical device adverse event reporting is an essential activity for mitigating device-related risks. Reporting of adverse events can be done by anyone like healthcare workers, patients, and others. However,...
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