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Effect of Iron-Chelator Deferiprone on the In Vitro Growth of Staphylococci

Kim CM, Shin SH

The standard iron-chelator deferoxamine is known to prevent the growth of coagulase-negative staphylococci (CoNS) which are major pathogens in iron-overloaded patients. However, we found that deferoxamine rather promotes the growth...
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Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells

Kim DS, Na YJ, Kang MH, Yoon SY, Choi CW

BACKGROUND/AIMS: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed,...
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Iron chelator inducesMIP-3alpha/CCL20 in human intestinal epithelial cells: implication for triggeringmucosal adaptive immunity

Lee HJ, Choi SC, Choi EY, Lee MH, Seo GS, Kim EC, Yang BJ, Lee MS, Shin YI, Park KI, Jun CD

  • KMID: 1093465
  • Exp Mol Med.
  • 2005 Aug;37(4):297-310.
A previous report by this laboratory demonstrated that bacterial iron chelator (siderophore) triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs). Microarray-based gene...
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