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RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study

Wang XW, Wei W, Wang WQ, Zhao XY, Guo H, Fang DC

BACKGROUND/AIMS: To investigate the differential expression of RING finger (RNF) proteins in Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). METHODS: The differential expression of RNFs in normal esophagus (NE), BE, and...
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Molecules and their functions in autophagy

Pyo JO, Nah J, Jung YK

Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved...
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Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells

Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K

Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have...
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Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells

Mutoh H, Sashikawa , Sakamoto H, Tateno T

BACKGROUND/AIMS: Doublecortin and CaM kinase-like-1 (DCAMKL1) is a marker of stem cells expressed predominantly in the crypt base in the intestine. However, DCAMKL1-positive cells have been shown to be differentiated...
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The function of p27(KIP1) during tumor development

Lee J, Kim SS

Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitors (CKIs) which...
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Identification of Proteins That Interact with Podocin Using the Yeast 2-Hybrid System

Park SJ, Lee BH, Kim DJ

  • KMID: 2396072
  • Yonsei Med J.
  • 2009 Apr;50(2):273-279.
PURPOSE: As a membrane protein at the insertion site of the slit diaphragm (SD) complex in podocyte foot processes, podocin has been reported to act as a scaffolding protein required...
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Frequent Epigenetic Inactivation of XAF1 by Promotor Hypermethylation in Human Colon Cancers

Jang JY, Kim HJ, Chi SG, Lee KY, Nam KD, Kim NH, Lee SK, Joo KR, Dong SH, Kim BH, Chang YW, Lee JI, Chang R

  • KMID: 772766
  • Korean J Gastroenterol.
  • 2005 Apr;45(4):285-293.
BACKGROUND/AIMS: X-linked inhibitor of apoptosis (XIAP) is the most potent member of the IAP family that exerts antiapoptotic effects. Recently, XIAP-associated factor 1 (XAF1) and two mitochondrial proteins, Smac/DIABLO...
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The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats

Kim SH, Jang YW, Hwang P, Kim HJ, Han GY, Kim CW

Diabetic nephropathy (DN) is a progressive kidney disease that is caused by injury to kidney glomeruli. Podocytes are glomerular epithelial cells and play critical roles in the glomerular filtration barrier....
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DNA Double Strand Breaks in Gastric Epithelium with Helicobacter pylori Infection

Chang YJ, Byun SW, Kim HK, Cho YS, Kim SS, Kim JI, Kim JK, Jung ES

BACKGROUND/AIMS: DNA double strand breaks (DSB) is one of the critical types of DNA damage. If unrepaired, DSB is accumulated in the nucleus of cells, the cells become apoptotic or...
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