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Antimicrobial effect of Australia propolis on cariogenic and periodontopathic bacteria

Lim YK, Yoo SY, Lee DS, Kook JK

The purpose of this study was to investigate the antimicrobial effects of Australia propolis against cariogenic and periodontopathic bacteria. Antimicrobial activity was determined by evaluating the minimal bactericidal concentration (MBC)....
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Apelin-APJ axis inhibits TNF-alpha-mediated expression of genes involved in the inflammatory response in periodontal ligament cells

Lee G, Song WH, Kim SJ, Kim YG, Ryu JH

Periodontitis is an inflammatory disease of the supportive tissues surrounding the teeth, and is characterized by irreversible destruction of the gingiva, periodontal ligament (PDL), and alveolar bone, which results in...
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CCR5 deficiency in aged mice causes a decrease in bone mass

Oh EJ, Zang Y, Kim JW, Lee MN, Song JH, Oh SH, Kwon SH, Yang JW, Koh JT

The CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor that regulates chemotaxis and effector functions of immune cells. It also serves as the major co-receptor for the entry...
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Discovery and characterization of berberine derivatives as stimulators of osteoblast differentiation

Han Y, Park WJ

Berberine has been used clinically for more than a decade to treat various diseases, has been shown to be effective in osteoblast differentiation, and is a potential treatment option for...
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Comparison of inflammatory cytokine-inducing activity of lipopolysaccharides from major periodontal bacteria

Kim SH, Kang IC

Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn) are major periodontal pathogens. Lipopolysaccharides (LPSs) from periodontal bacteria play an important role in...
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Weissella cibaria CMU suppresses mgl gene expression and enzyme activity associated with bad breath

Kim HJ, Yeu JE, Lee DS, Kang MS

The oral care probiotic strain Weissella cibaria CMU (oraCMU) inhibits volatile sulphur compounds associated with halitosis, presumably by inhibiting the growth of associated oral pathogens. In the present study, we...
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Effect of the hedgehog signaling pathway on hair formation-related cells

Park J, Park S, Seo J, Roh S

Alopecia has emerged as one of the biggest interests in modern society. Many studies have focused on the treatment of alopecia, such as transplantation of hair follicles or inhibition of...
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Effects of plant-derived natural products on inflammatory bone destructive disease

Ko SY

Rheumatoid arthritis, osteoarthritis, and periodontal disease are bone destructive diseases mainly caused by inflammation. Various studies are being conducted to develop treatments for inflammatory bone destructive diseases. Many of these...
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An overview of the endocrine functions of osteocalcin

Baek K

Osteocalcin is the most abundant non-collagenous protein produced in bone. It has traditionally been regarded as a marker of bone turnover and is thought to act in the bone matrix...
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