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Immunostimulatory Effects of beta-glucan Purified from Paenibacillus polymyxa JB115 on Mouse Splenocytes

Kim JM, Joo HG

We investigated the effects of beta-glucan purified from Paenibacillus polymyxa JB115 on the viability and proliferation of splenocytes. Splenocytes play a critical role in host immunity. MTT assays and trypan...
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Interleukin-7 Receptor is Indispensable for Proliferation and Survival in Thymic gamma sigma T Cell Development

Kim DH, Yoon BH, Jung JE, Kim HS, Ko SH, Choi EY, Lee KH, Kim K, Ye SK, Chung MH

BACKGROUND: Interleukin-7 receptor (IL-7R) alpha-deficient mice have small numbers of B cells and alpha beta T cells in periphery, they totally lack gamma sigma T cells. In addition, the V-J...
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Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets

Park R, Kim TH, Ji JD

OBJECTIVE: To identify a gene expression signature in axial spondyloarthritis/ankylosing spondylitis (SpA/AS) and genomic pathways likely to be involved in pathogenesis of SpA/AS patients. METHODS: Four publicly accessible microarray studies from...
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Codelivery of IL-7 Augments Multigenic HCV DNA Vaccine-induced Antibody as well as Broad T Cell Responses in Cynomolgus Monkeys

Park SH, Song MY, Nam HJ, Im SJ, Sung YC

BACKGROUND: A crucial limitation of DNA vaccines is its weak immunogenicity, especially in terms of eliciting antibody responses in non-human primates or humans; therefore, it is essential to enhance immune...
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Generation of CD2+CD8+ NK Cells from c-kit+ Bone Marrow Cells in Porcine

Lim KH, Han JH, Roh YS, Kim B, Kwon JK, You MJ, Han HJ, Ejaz S, Kang CW, Kim JH

Natural killer (NK) cells provide one of the initial barriers of cellular host defense against pathogens, in particular intracellular pathogens. Because bone marrow-derived hematopoietic stem cells (HSCs), lymphoid protenitors, can...
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RANKL stimulates proliferation, adhesion and IL-7 expression of thymic epithelial cells

Lee HW, Park HK, Na YJ, Kim CD, Lee JH, Kim BS, Kim JB, Lee CW, Moon JO, Yoon S

Abstract In many clinical situations which cause thymic involution and thereby result in immune deficiency, T cells are the most often affected, leading to a prolonged deficiency of T cells. Since...
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