- Partial purification and characterization of a novel murine factor that augments the expression of class I MHC antigens on tumor cells
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Puri N, Saxena RK
- KMID: 754994
- Exp Mol Med.
- 1998 Jun;30(2):93-99.
A soluble factor which augments the expression of major histocompatibility complex class I (MHC I) antigens on a number of murine tumor cell lines, has been isolated from the culture supernatants of... -
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- Monophosphoryl lipid A (MPL) upregulates major histocompatibility complex (MHC) class I expression by increasing interferon-gamma (IFN-gamma)
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Cho CH, Lee BK, Kwak SM, Kim JD
- KMID: 1099874
- Yonsei Med J.
- 1999 Feb;40(1):20-25.
- doi: 10.3349/ymj.1999.40.1.20
Tumor immunity is primarily mediated by cells as CD8+ cytotoxic T lymphocytes (CTL) recognize tumor antigen by MHC class I molecules. But most tumors are associated with a... -
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- Receptor activator of NF-kappaB ligand enhances the activity of macrophages as antigen presenting cells
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Park H, Park OJ, Shin J, Choi Y
- KMID: 1116197
- Exp Mol Med.
- 2005 Dec;37(6):524-532.
Receptor activator of NFkappaB ligand (RANKL) is known as a key regulator of osteoclastogenesis. However, the fact that fibroblasts and periodontal ligament cells express RANKL in response to bacterial substances,... -
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- The role of nitric oxide as an effector of macrophage-mediated cytotoxicity against Trichomonas vaginalis
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Park GC, Ryu JS, Min DY
- KMID: 658271
- Korean J Parasitol.
- 1997 Sep;35(3):189-195.
- doi: 10.3347/kjp.1997.35.3.189
The purpose of this study is to determine whether nitric oxide is involved in the extracellular killing of Trichomonas vaginalis by mouse (BALB/c) peritoneal macrophages and RAW264.7 cells... -
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- Interferon-gamma upregulates the stromelysin-1 gene expression by human skin fibroblasts in culture
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Lee KS, Ryoo YW, Song JY
- KMID: 754989
- Exp Mol Med.
- 1998 Jun;30(2):59-64.
The equilibrium between deposition and degradation of extracellular matrix(ECM) is essential to normal tissue development and repair of wound or inflammatory responses. It has recently become apparent that several cytokines and growth factors... -
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- Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents
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Kim SA, Kang JH, Cho IH, Bae SW, Hong KJ
- KMID: 938874
- Exp Mol Med.
- 2001 Sep;33(3):117-123.
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly... -
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- Modulation of the Surface Expression of CD158 Killer Cell Ig-like Receptor by Interleukin-2 and Transforming Growth Factor-beta
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Shin EC, Choi KS, Kim SJ, Shin JS
- KMID: 1734134
- Yonsei Med J.
- 2004 Jun;45(3):510-514.
- doi: 10.3349/ymj.2004.45.3.510
Killer cell Ig-like receptor (KIR) binds to HLA class I molecules on the surface of target cells, and it confers inhibitory signals to NK cells. Although NK cytotoxicity can be... -
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- Induction of nitric oxid esynthase(NOS) by soluble glucocorticoid induced tumor necrosis factor receptor(sGITR) is modulated by IFN-g in murine macrophage
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Shin HH, Lee HW, Choi HS
- KMID: 1094698
- Exp Mol Med.
- 2003 Jun;35(3):175-180.
Earlier study showed that glucocorticoid induced tumor necrosis factor receptor (GITR), a new TNFR family, activated murine macrophages to express inducible nitric oxide synthase (iNOS) and to generate nitric oxide... -
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- Soluble factor from tumor cells induces heme oxygenase-1 by a nitric oxide-independent mechanism in murine peritoneal macrophages
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Kim SW, Oh HM, Kim BS, Chung HT, Han WC, Kim EC, Kim TH, Seo GS, Lyou JH, Nah YH, Jung JC, Choi SC, Jun CD
- KMID: 1088658
- Exp Mol Med.
- 2003 Feb;35(1):53-59.
Tumor target-derived soluble secretary factor has been known to influence macrophage activation to induce nitric oxide (NO) production. Since heme oxigenase-1 (HO-1) is induced by a variety of conditions associated... -
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- Delayed allograft rejection by the suppression of class II transactivator
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Kim TW, Choi YM, Seo JN, Kim JH, Suh YH, Chung DH, Jung KC, Oh KI
- KMID: 1094146
- Exp Mol Med.
- 2006 Jun;38(3):210-216.
We examined the effect of class II transactivator (CIITA) down-modulation on allograft rejection. To inhibit the function of CIITA, we constructed a series of CIITA mutants and found one exhibiting... -
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- Molecular analysis of HLA-DR gene expression induced by IFN-gamma in malignant melanoma cell lines
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Lee JL, Kim YH, Lee JM, Kim JD, Kim SJ, Park JH
- KMID: 1099876
- Yonsei Med J.
- 1999 Feb;40(1):30-39.
- doi: 10.3349/ymj.1999.40.1.30
Human leukocyte antigen (HLA) class II molecules are polymorphic cell surface glycoproteins that are crucial for the cellular interaction in immune response. The expression of class II molecules... -
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- Phagocytosis of serum-and IgG-opsonized zymos an particles induces apoptosis through superoxide but not nitric oxide in macrophage J774A.1
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Kim JS, Kwon HY, Choi WH, Jeon CY, Kim JI, Kim J, Lee JY, Kim YS, Park JB
- KMID: 1094703
- Exp Mol Med.
- 2003 Jun;35(3):211-221.
Phagocytosis of serum- and IgG-opsonized zymosan (SOZ and IOZ, respectively) particles into J774A.1 macrophages induced apoptosis of the cells, accompanied by the expression of p21(WAF1), one of cyclin-dependent protein kinase... -
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