- Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells
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Ma WN, Park SY, Han JS
- KMID: 1078361
- Exp Mol Med.
- 2010 Jun;42(6):456-464.
- doi: 10.3858/emm.2010.42.6.047
As glucose is known to induce insulin secretion in pancreatic beta cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high... -
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- The Effect of Early Insulin Therapy on Pancreatic beta-Cell Function and Long-Term Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients
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Chon S, Oh S, Kim SW, Kim JW, Kim YS, Woo JT
- KMID: 1776608
- Korean J Intern Med.
- 2010 Sep;25(3):273-281.
- doi: 10.3904/kjim.2010.25.3.273
BACKGROUND/AIMS: Based on the results of well designed clinical studies, intensive insulin therapy has been established to improve glycemic control in newly diagnosed diabetes. However, discrepancies exist between the findings... -
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- Sulfuretin protects against cytokine-induced beta-cell damage and prevents streptozotocin-induced diabetes
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Song MY, Jeong GS, Kwon KB, Ka SO, Jang HY, Park JW, Kim YC, Park BH
- KMID: 983955
- Exp Mol Med.
- 2010 Sep;42(9):628-638.
- doi: 10.3858/emm.2010.42.9.062
NF-kappaB activation has been implicated as a key signaling mechanism for pancreatic beta-cell damage. Sulfuretin is one of the main flavonoids produced by Rhus verniciflua, which is reported to inhibit... -
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- The efficacy of SPA0355 in protecting beta cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes
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Bae UJ, Song MY, Jang HY, Gim HJ, Ryu JH, Lee SM, Jeon R, Park BH
- KMID: 2154270
- Exp Mol Med.
- 2013 Nov;45(11):e51.
Cytokines activate several inflammatory signals that mediate beta-cell destruction. We recently determined that SPA0355 is a strong anti-inflammatory compound, thus reporting its efficacy in protecting beta cells from various insults.... -
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- Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity-Associated Type 2 Diabetes
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Jin SM, Oh BJ, Lee S, Choi JM, Yang SJ, Park SW, Kim KW, Kim JH, Park CY
- KMID: 1793159
- Yonsei Med J.
- 2013 Sep;54(5):1127-1136.
- doi: 10.3349/ymj.2013.54.5.1127
PURPOSE: Although the presence of cannabinoid type 1 (CB1) receptor in islets has been reported, the major contributor to the protective effect of rimonabant on islet morphology is unknown. We... -
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