- A Protective Role for Heme Oxygenase-1 in INS-1 Cells and Rat Islets that are Exposed to High Glucose Conditions
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Won KC, Moon JS, Eun MJ, Yoon JS, Chun KA, Cho IH, Kim YW, Lee HW
- KMID: 1778421
- J Korean Med Sci.
- 2006 Jun;21(3):418-424.
- doi: 10.3346/jkms.2006.21.3.418
Heme oxygenase-1 (HO-1) has been described as an inducible protein that is capable of cytoprotection via radical scavenging and the prevention of apoptosis. Chronic exposure to hyperglycemia can lead to... -
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- Functional improvement of porcine neonatal pancreatic cell clusters via conformal encapsulation using an air-driven encapsulator
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Park SJ, Shin S, Koo OJ, Moon JH, Jang G, Ahn C, Lee BC, Yoo YJ
- KMID: 1120138
- Exp Mol Med.
- 2012 Jan;44(1):20-25.
- doi: 10.3858/emm.2012.44.1.001
Transplantation of islet cells into diabetic patients is a promising therapy, provided that the islet cells are able to evade host immune rejection. With improved islet viability, this strategy may... -
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- Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation
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Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH
- KMID: 1094655
- Exp Mol Med.
- 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma... -
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- Effect of Hypophysectomy, Adrenalectomy, and Thyroidectomy on the Beta-Cells of the Islets of Langerhans of the Pancreas
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Lee HJ, Lee YB, Kim DS
- KMID: 687607
- Yonsei Med J.
- 1969 Jun;10(1):1-9.
- doi: 10.3349/ymj.1969.10.1.1
Prolonged administration of anterior hypophyseal, adrenocortical, or thyroid hormones is known to cause degeneration, degranulation and necrosis of the beta-cells in the Langerhans islets of the pancreas. However, the effects... -
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- Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP
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Rho HW, Lee JN, Kim HR, Park BH, Park JW
- KMID: 927128
- Exp Mol Med.
- 2000 Mar;32(1):12-17.
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian... -
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- Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice
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Chae HY, Lee BW, Oh SH, Ahn YR, Chung JH, Min YK, Lee MS, Lee MK, Kim KW
- KMID: 1116196
- Exp Mol Med.
- 2005 Dec;37(6):513-523.
Hypoxic damage is one of the major causes of islet graft failure and VEGF is known to play a crucial role in revascularization. To address the effectiveness of a cationic... -
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