- B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells
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Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
- KMID: 2154244
- Exp Mol Med.
- 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a... -
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- Microarray for Genes Associated with Signal Transduction in Diabetic OLETF Keratocytes
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Lee JE, Lee JS, Hwang SH
- KMID: 1101914
- Korean J Ophthalmol.
- 2007 Jun;21(2):111-119.
- doi: 10.3341/kjo.2007.21.2.111
PURPOSE: The purpose of this study was to identify differences in signal transduction gene expression between normal and diabetic keratocytes stimulated with interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha). ... -
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- The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
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Yoon JS, Moon JS, Kim YW, Won KC, Lee HW
- KMID: 2363693
- J Korean Med Sci.
- 2016 Apr;31(4):547-552.
- doi: 10.3346/jkms.2016.31.4.547
Inhibition of CD36, a fatty acid transporter, has been reported to prevent glucotoxicity and ameliorate high glucose induced beta cell dysfunction. Ezetimibe is a selective cholesterol absorption inhibitor that blocks... -
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- Exendin-4 Protects Oxidative Stress-Induced beta-Cell Apoptosis through Reduced JNK and GSK3beta Activity
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Kim JY, Lim DM, Moon CI, Jo KJ, Lee SK, Baik HW, Lee KH, Lee KW, Park KY, Kim BJ
- KMID: 1779233
- J Korean Med Sci.
- 2010 Nov;25(11):1626-1632.
- doi: 10.3346/jkms.2010.25.11.1626
Oxidative stress induced by chronic hyperglycemia in type 2 diabetes plays a crucial role in progressive loss of beta-cell mass through beta-cell apoptosis. Glucagon like peptide-1 (GLP-1) has effects on... -
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