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Differential effect of homocysteic acid and cysteic acid on changes of inositol phosphates and (Ca2+)i in rat cerebellar granule cells

Kim WK, Pae YS

  • KMID: 2071522
  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):41-48.
The present study was undertaken to characterize homocysteic acid (HCA)-and cysteic acid (CA)mediated formation of inositol phosphates (InsP) in primary culture of rat cerebellar granule cells. HCA and CA stimulated InsP formation in...
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EGF-stimulated aldosterone secretion is mediated by tyrosine phosphorylation but not by phospholipase C in cultured porcine adrenal glomerulosa cells

Kim SY, Park DJ, Lee HK

We examined the effect of EGF and angiotensin II (AII) on the formation of inositol phosphates and aldosterone secretion, and observed the role of tyrosine phosphorylation in EGF or...
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Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells

Lee YM, Kim HJ, Hong SH, Kim MJ, Min DS, Rhie DJ, Kim MS, Jo YH, Hahn SJ, Yoon SH

  • KMID: 1517038
  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):57-63.
Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based...
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Mercury Promotes Catecholamines Which Potentiate Mercurial Autoimmunity and Vasodilation: Implications for Inositol 1,4,5-Triphosphate 3-Kinase C Susceptibility in Kawasaki Syndrome

Yeter D, Deth R, Kuo HC

Previously, we reviewed biological evidence that mercury could induce autoimmunity and coronary arterial wall relaxation as observed in Kawasaki syndrome (KS) through its effects on calcium signaling, and that inositol...
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Differential Expressions of Apoptosis-related Genes in Lung Cancer Cell Lines Determine the Responsiveness to Ionizing Radiation

Lee SY, Choi MK, Lim JM, Wu HG, Kim JH, Park WY

  • KMID: 2166320
  • Genomics Inform.
  • 2008 Mar;6(1):36-43.
Radiotherapy would be the choice of treatment for human cancers, because of high cost-effectiveness. However, a certain population of patients shows a resistance to radiotherapy and recurrence. In an effort...
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The effects of superoxide dismutase on the expression of c-fos gene in the chronic post-ischemic pain model rats

Kim TK, Shin SW, Jung H, Lim DG

BACKGROUND: Chronic post-ischemia pain (CPIP) model is reported to represent the complex regional pain syndrome type I. The administration of non-specific free radical scavengers reduced mechanical allodynia, but it is...
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Apoptosis of the GABAergic interneuron in the dorsal horn of the chronic post-ischemic pain model

Park JH, Kim TK, Kim HK, Baik SW

BACKGROUND: It is well known that the GABAergic inhibitory interneuronal system plays an important role in modulation of the noxious stimulation transmitted from the primary afferent input. Some studies have...
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Contralateral allodynia and central change in the chronic post-ischemic pain model rats

Kwak KH, Jung KY, Choi JY, Ryu T, Yeo JS, Park SS, Lim DG, Kim SO, Baek WY, Hong JG

BACKGROUND: Mirror-image allodynia is a mysterious phenomenon that occurs in association with many clinical pain syndromes including complex regional pain syndromes (CRPS). Underlying mechanisms for the development of such pain...
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Antiallodynic effects of vitamin C and vitamin E in chronic post-ischemia pain rat model

Park JM, Kim CK, Lee HC, Jung H, Choi KU, Hong SW, Lim DG, Baek WY, Kwak KH

BACKGROUND: Recent research has shown that reactive oxygen species (ROS) play a significant role in the development and persistence of neuropathic pain through central sensitization via N-methyl-D-aspartate (NMDA) receptor activation....
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Superoxide and Nitric Oxide Involvement in Enhancing of N-methyl-D-aspartate Receptor-Mediated Central Sensitization in the Chronic Post-ischemia Pain Model

Ryu TH, Jung KY, Ha MJ, Kwak KH, Lim DG, Hong JG

  • KMID: 2392739
  • Korean J Pain.
  • 2010 Mar;23(1):1-10.
BACKGROUND: Recent studies indicate that reactive oxygen species (ROS) are involved in persistent pain, including neuropathic and inflammatory pain. Since the data suggest that ROS are involved in central sensitization,...
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