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Inhibition of MicroRNA-15a/16 Expression Alleviates Neuropathic Pain Development through Upregulation of G Protein-Coupled Receptor Kinase 2

Li T, Wan Y, Sun L, Tao S, Chen P, Liu C, Wang K, Zhou C, Zhao G

There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in...
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Sequential intrathecal injection of fentanyl and hyperbaric bupivacaine at different rates: does it make a difference? A randomized controlled trial

Hussien RM, Rabie AH

BACKGROUND: Previous studies have shown that sequential intrathecal injection of fentanyl and hyperbaric bupivacaine for cesarean section (CS) anesthesia provides a superior anesthetic effect than use of bupivacaine alone, and...
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Feasibility of Ultrasound-Guided Lumbar and S1 Nerve Root Block: A Cadaver Study

Kim J, Park HJ, Lee WI, Won SJ

OBJECTIVE: This study evaluated the feasibility of ultrasound-guided lumbar nerve root block (LNRB) and S1 nerve root block by identifying spread patterns via fluoroscopy in cadavers. METHOD: A total of 48...
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The Evidence for Nonoperative Treatment of Lumbar Spinal Diseases

Kim HS, Ahn DK, Seo HY, Kim CS, Kim MJ

STUDY DESIGN: Review article. OBJECTIVES: To assess the evidence for nonoperative treatment of various degenerative spinal degenerative diseases. SUMMARY OF LITERATURE REVIEW: No study has yet evaluated the evidence for preoperative nonoperative...
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Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodefi ciency Mice: Preclinical Study

Quesada MP, García-Bernal D, Pastor D, Estirado A, Blanquer M, García-Hernández AM, Moraleda J, Martínez

BACKGROUND: Mesenchymal stromal cells (MSCs) have potent immunomodulatory and neuroprotective properties, and have been tested in neurodegenerative diseases resulting in meaningful clinical improvements. Regulatory guidelines specify the need to perform...
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Participation of Opioid Pathway in the Central Antinociceptive Effects of Eugenol

Kang SH, Kang SW, Kim JH, Kim HY, Ryu HS, Bae SY, Oh JA, Lee JH, Hyun JH, Ahn DK

The aim of the present study was to evaluate the central antinociceptive effects of eugenol after intraperitoneal administration. Experiments were carried out using male Sprague-Dawley rats. Subcutaneous injection of 5%...
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Effects of High Concentrations of Naftopidil on Dorsal Root-Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro

Uta D, Hattori T, Yoshimura

PURPOSE: Naftopidil ((±)-1-[4-(2-methoxyphenyl) piperazinyl]-3-(1-naphthyloxy) propan-2-ol) is prescribed in several Asian countries for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Previous animal experiments showed that intrathecal injection of naftopidil...
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Sensory and Motor Behavior Evidences Supporting the Usefulness of Conditioned Medium from Dental Pulp-Derived Stem Cells in Spinal Cord Injury in Rats

Asadi-Golshan R, Razban V, Mirzaei E, Rahmanian , Khajeh S, Mostafavi-Pour Z, Dehghani F

STUDY DESIGN: Experimental animal study. PURPOSE: This study aimed to assess effects of conditioned medium (CM) of dental pulp-derived stem cells loaded in collagen hydrogel on functional recovery following spinal cord...
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Morphologic changes in the spinal cord following intrathecal palonosetron-HCl injection in rats

Yoo SH, Chung JH, Seo Y, Choi MK, Choi WK, Kim JB

BACKGROUND: Intravenous palonosetron-HCl, a second-generation antagonist of selective serotonin type 3 (5-HT3) receptors, can prevent chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). 5-HT3 receptors are abundant...
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The Effects of Comprehensive Education Program on Anxiety, Uncertainty and Athletic Performance of Patients undergo Spinal Nerve Block

Kim SH, Lee ES

PURPOSE: Purpose of the study was to identify the effect of the Comprehensive Education Program (CEP) on intraprocedure anxiety, post-procedure uncertainty and athletic performance of back strengthening of patients undergo...
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Analysis of medical disputes regarding chronic pain management in the 2009–2016 period using the Korean Society of Anesthesiologists database

Lee JY, Kim DK, Jung DW, Yang JY, Kim DY

BACKGROUND: The active involvement of anesthesiologists in chronic pain management has been associated with an increase in the number of related medical dispute cases. METHODS: Using the Korean Society of Anesthesiologists...
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Implantable drug delivery systems with morphine in fibromyalgia: A case report

Ju YM, Shin SH, Choi SC, Chon JY, Sung CH, Moon HS

The fibromyalgia syndrome (FMS) could be approached by various treatments modalities including education, aerobic exercise, cognitive behavioral therapy, tricyclic antidepressants, serotonin norepinephrine reuptake inhibitors, pregabalin, and so on. If other...
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Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

Li D, Yan Y, Yu L, Duan Y

Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its...
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Treatment of Cerebral Palsy with Stem Cells: A Report of 17 Cases

Abi Chahine NH, Wehbe TW, Hilal RA, Zoghbi VV, Melki AE, Bou Habib

Cerebral Palsy (CP) is a disabling condition that affects a child's life and his/her family irreversibly. It is usually a non-progressive condition but improvement over time is rarely seen. The...
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Intrathecal Trastuzumab Treatment in Patients with Breast Cancer and Leptomeningeal Carcinomatosis

Park WY, Kim HJ, Kim K, Bae SB, Lee N, Lee KT, Won JH, Park HS, Lee SC

Leptomeningeal carcinomatosis is a fatal manifestation of metastatic breast cancer. Investigation of intrathecal (IT) trastuzumab for leptomeningeal carcinomatosis is currently underway; however, there has been no consensus. We report on...
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Palonosetron might not attenuate spinal anesthesia-induced hypotension during orthopedic surgery

Choi JJ, Chang YJ, Jung WS, Jo YY

BACKGROUND: 5-Hydroxytryptamine3 (5-HT3) receptor antagonists have been reported to attenuate spinal anesthesia-induced hemodynamic changes. This study was conducted to determine whether the second generation 5-HT3, antagonist palonosetron attenuates hypotension and...
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Acute Effects of Transforming Growth Factor-β1 on Neuronal Excitability and Involvement in the Pain of Rats with Chronic Pancreatitis

Zhang X, Zheng H, Zhu HY, Hu S, Wang S, Jiang X, Xu GY

  • KMID: 2203587
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):333-343.
  • doi: 10.5056/jnm15127
BACKGROUND/AIMS: This study was to investigate whether transforming growth factor-β1 (TGF-β1) plays a role in hyperalgesia in chronic pancreatitis (CP) and the underlying mechanisms. METHODS: CP was induced in male adult...
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Intrathecal Morphine Infusion Therapy in Management of Chronic Pain: Present and Future Implementation in Korea

Kim EJ, Moon JY, Kim YC, Park KS, Yoo YJ

PURPOSE: Intrathecal morphine pump (ITMP) infusion therapy is efficient in managing malignant and nonmalignant chronic pain refractory to standard treatment. However, the high cost of an ITMP is the greatest...
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The Effect and Safety of Steroid Injection in Lumbar Spinal Stenosis: With or Without Local Anesthetics

Song SH, Ryu GH, Park JW, Lee HJ, Nam KY, Kim H, Kim SY, Kwon BS

OBJECTIVE: To compare the long-term effect and safety of an epidural steroid injection in spinal stenosis patients, with or without local anesthetics. METHODS: Twenty-nine patients diagnosed with spinal stenosis were included...
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The Synergistic Effect of Intrathecally Administered Dexmedetomidine and Ketorolac on Mechanical Allodynia in Rats with Spinal Nerve Ligation

Cheong YK, Kim YD, Lee JH, Ham HD, Choi SW, Park SJ

OBJECTIVES: This research was carried out to identify the synergistic effect of dexmedetomidine and ketorolac on neuropathic pain alleviation. METHODS: The anti-allodynic effect of intrathecal dexmedetomidine and ketorolac was investigated in...
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