- Breakthrough in heart failure with preserved ejection fraction: are we there yet?
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Lim SL, Lam CS
- KMID: 2373767
- Korean J Intern Med.
- 2016 Jan;31(1):1-14.
- doi: 10.3904/kjim.2016.31.1.1
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective... -
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- B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages
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Kim MY, Kim DH, Do MS
- KMID: 2154223
- Exp Mol Med.
- 2013 Jan;45(1):e4.
3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore, BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-alpha and rosiglitazone. Here we... -
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- Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
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Kim YS, Joh TH
- KMID: 1110117
- Exp Mol Med.
- 2006 Aug;38(4):333-347.
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's... -
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- Effects of oncostatin M on hormone release of rat pituitary cells in primary culture
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Kim DS, Choi HS, Park YS, Kim TW
- KMID: 1128632
- J Korean Med Sci.
- 2000 Jun;15(3):323-326.
- doi: 10.3346/jkms.2000.15.3.323
It has become increasingly clear that cytokines play an important role in modulating neuroendocrine regulation, especially in the secretion of corticotropin (ACTH) in the pituitary. Oncostatin M (OSM), a cytokine... -
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- MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis
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Lee DG, Woo JW, Kwok SK, Cho ML, Park SH
- KMID: 2154239
- Exp Mol Med.
- 2013 Apr;45(4):e20.
Myeloid-related protein (MRP)8/MRP14 is an endogenous Toll-like receptor 4 (TLR4) ligand and is abundant in synovial fluid (SF) of rheumatoid arthritis (RA) patients. Belonging to damage-associated molecular patterns, it amplifies... -
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- Nonalcoholic Fatty Liver Disease
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Ko JS
- KMID: 1775872
- Korean J Gastroenterol.
- 2010 Jul;56(1):6-14.
- doi: 10.4166/kjg.2010.56.1.6
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and is commonly associated with obesity. The spectrum of NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis (NASH)... -
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- The dose of cyclophosphamide for treating paraquat-induced rat lung injury
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Choi JS, Jou SS, Oh MH, Kim YH, Park MJ, Gil HW, Song HY, Hong SY
- KMID: 1503779
- Korean J Intern Med.
- 2013 Jul;28(4):420-427.
- doi: 10.3904/kjim.2013.28.4.420
BACKGROUND/AIMS: Cyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury. METHODS: Adult male Sprague-Dawley rats... -
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- Applications of systems approaches in the study of rheumatic diseases
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Kim KJ, Lee S, Kim WU
- KMID: 2160677
- Korean J Intern Med.
- 2015 Mar;30(2):148-160.
- doi: 10.3904/kjim.2015.30.2.148
The complex interaction of molecules within a biological system constitutes a functional module. These modules are then acted upon by both internal and external factors, such as genetic and environmental... -
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- Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression
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Kim DH, Cho IH, Kim HS, Jung JE, Kim JE, Lee KH, Park T, Yang YM, Seong SY, Ye SK, Chung MH
- KMID: 1110126
- Exp Mol Med.
- 2006 Aug;38(4):417-427.
To elucidate the roles of 8-hydroxydeoxyguanosine (oh8dG), the nucleoside of 8-hydroxyguanine (oh8Gua), we examined the effects of oh8dG upon LPS-induced intercellular adhesion molecule-1 (ICAM-1) expression and the underlying mechanisms in... -
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- Role of Staphylococcal Superantigen in Atopic Dermatitis: Influence on Keratinocytes
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Kim KH, Han JH, Chung JH, Cho KH, Eun HC
- KMID: 1781842
- J Korean Med Sci.
- 2006 Apr;21(2):315-323.
- doi: 10.3346/jkms.2006.21.2.315
Staphylococcus aureus may perform an crucial function in atopic dermatitis (AD), via the secretion of superantigens, including staphylococcal enterotoxins (SE) A or B, and toxic shock syndrome toxin-1 (TSST-1). Dysregulated... -
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- Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema
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Gamze K, Mehmet HM, Deveci F, Turgut T, ilhan F, Ozercan I
- KMID: 1090964
- Exp Mol Med.
- 2007 Oct;39(5):614-620.
Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to... -
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