- The Soluble Tumor Necrosis Factor-Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma
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Nam HS, Lee SY, Kim SJ, Kim JS, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH, Kim SC
- KMID: 1758619
- Yonsei Med J.
- 2009 Aug;50(4):569-575.
- doi: 10.3349/ymj.2009.50.4.569
PURPOSE: Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma. TNF-alpha blocking strategies are now being tried in... -
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- Attenuation of airway inflammation by simvastatin and the implications for asthma treatment: is the jury still out?
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Liu JN, Suh DH, Yang EM, Lee SI, Park HS, Shin YS
- KMID: 2155378
- Exp Mol Med.
- 2014 Sep;46(9):e113.
- doi: 10.1038/emm.2014.55
Although some studies have explained the immunomodulatory effects of statins, the exact mechanisms and the therapeutic significance of these molecules remain to be elucidated. This study not only evaluated the... -
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- Erythropoietin Attenuates Hyperoxia-Induced Lung Injury by Down-modulating Inflammation in Neonatal Rats
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Lee JH, Sung DK, Koo SH, Shin BK, Hong YS, Son CS, Lee JW, Chang YS, Park WS
- KMID: 1785767
- J Korean Med Sci.
- 2007 Dec;22(6):1042-1047.
- doi: 10.3346/jkms.2007.22.6.1042
This study was done to determine whether recombinant human erythropoietin (rhEPO) treatment could attenuate hyperoxia-induced lung injury, and if so, whether this protective effect is mediated by the down-modulation of... -
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- A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells
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Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY
- KMID: 1383799
- Exp Mol Med.
- 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound... -
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